Different kenyon cell populations drive learned approach and avoidance in Drosophila.
Different kenyon cell populations drive learned approach and avoidance in Drosophila.
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DOI：
10.1016/j.neuron.2013.07.045
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发表时间：
2013-09-04
期刊：
影响因子：
16.2
通讯作者：
Waddell S
中科院分区：
文献类型：
--
作者：
Perisse E;Yin Y;Lin AC;Lin S;Huetteroth W;Waddell S
在果蝇中，解剖学上离散的多巴胺神经元支配蘑菇体（MB）的不同区域，在嗅觉学习过程中对气味分配相反的价。MB神经元的子集在记忆处理中具有时间上独特的作用，但与价相关的组织尚未得到证实。我们对αβ神经元进行了功能细分，揭示了αβ核心（αβc）神经元的价值特异性作用。阻断αβ表面（αβs）神经元的神经传递，显示了对反感记忆和食欲记忆检索的需求，而阻断αβc仅损害食欲记忆。αβc在差异厌恶范式中也需要表达记忆，这表明在相对评价和接近行为中起作用。引人注目的是，强化多巴胺神经元和传出通路对MB叶αβc和αβs的神经支配不同。我们提出条件方法需要汇集来自整个αβ集合的突触输出，但仅来自条件厌恶的αβs。不同的回路驱动习得性厌恶和接近。Perisse等人证明，离散的蘑菇体神经元群驱动果蝇习得性接近和回避行为。因此，对同一气味的厌恶记忆和食欲记忆在不同的神经系统中表现出来。
In Drosophila, anatomically discrete dopamine neurons that innervate distinct zones of the mushroom body (MB) assign opposing valence to odors during olfactory learning. Subsets of MB neurons have temporally unique roles in memory processing, but valence-related organization has not been demonstrated. We functionally subdivided the αβ neurons, revealing a value-specific role for the ∼160 αβ core (αβc) neurons. Blocking neurotransmission from αβ surface (αβs) neurons revealed a requirement during retrieval of aversive and appetitive memory, whereas blocking αβc only impaired appetitive memory. The αβc were also required to express memory in a differential aversive paradigm demonstrating a role in relative valuation and approach behavior. Strikingly, both reinforcing dopamine neurons and efferent pathways differentially innervate αβc and αβs in the MB lobes. We propose that conditioned approach requires pooling synaptic outputs from across the αβ ensemble but only from the αβs for conditioned aversion. Differential representation of memory valence in Drosophila mushroom body neurons αβ core neurons are specifically required for conditioned approach behavior Relative aversive learning requires rewarding dopaminergic reinforcement Distinct circuits drive learned aversion and approach Perisse et al. demonstrate that discrete mushroom body neuron populations drive learned approach and avoidance behaviors in the fruit fly. Aversive and appetitive memories for the same odor are therefore represented in different neural ensembles.
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DOI：
10.1523/jneurosci.1882-10.2010
发表时间：
2010-12-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Akalal DB;Yu D;Davis RL
通讯作者：
Davis RL
影响因子：
56.9
作者：
Isabel, G;Pascual, A;Preat, T
通讯作者：
Preat, T
影响因子：
4.5
作者：
Aso Y;Herb A;Ogueta M;Siwanowicz I;Templier T;Friedrich AB;Ito K;Scholz H;Tanimoto H
通讯作者：
Tanimoto H
影响因子：
64.5
作者：
Claridge-Chang A;Roorda RD;Vrontou E;Sjulson L;Li H;Hirsh J;Miesenböck G
通讯作者：
Miesenböck G
影响因子：
56.9
作者：
Chen, Chun-Chao;Wu, Jie-Kai;Chiang, Ann-Shyn
通讯作者：
Chiang, Ann-Shyn