Relationship between serum cortisol level and degree of false lumen thrombosis in patients with uncomplicated type B aortic dissection.
Relationship between serum cortisol level and degree of false lumen thrombosis in patients with uncomplicated type B aortic dissection.
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无并发症B型主动脉夹层患者血清皮质醇水平与假腔血栓形成程度的关系
DOI：
10.1038/s41598-018-19691-6
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发表时间：
2018-01-19
影响因子：
4.6
通讯作者：
Jing Z
中科院分区：
文献类型：
--
作者：
Wu Y;Sun Y;Wei X;Zhang L;Han T;Zhao Z;Zhou J;Jing Z
无并发症的B型主动脉夹层（uTBAD）假腔部分血栓形成与晚期死亡风险增加相关。血清皮质醇水平是否会影响uTBAD患者的假腔血栓形成尚未得到很好的表征。本研究在87例uTBAD患者中进行。采用曲线拟合法分析血清皮质醇与假腔部分血栓形成的关系。单变量和多变量逻辑回归分析用于识别假腔部分血栓形成相关的血清皮质醇。曲线拟合结果显示特征性U形，14.0 µg/dL被认为是血清皮质醇的临界点。单因素和多因素Logistic回归分析结果表明，将血清皮质醇水平分为三部分时，低水平和高水平血清皮质醇较中等水平血清皮质醇对假腔部分血栓形成的影响更显著。单因素分析中，血清皮质醇低水平和高水平的比值比值分别为6.12和4.65，多因素分析中，比值比值分别为24.32和3.93。血清皮质醇水平的高低可能通过影响假腔血栓形成而影响uTBAD的自然结果。
Partial thrombosis of the false lumen in uncomplicated type B aortic dissection (uTBAD) is associated with an increased late mortality risk. Whether the serum cortisol level can affect false lumen thrombosis in patients with uTBAD has not been well characterized. This study was performed on 87 patients with uTBAD. A curve-fitting method was used to analyze the relationship between serum cortisol and partial thrombosis of false lumen. Univariate and multivariate logistic regression analyses were used to identify false lumen partial thrombosis–associated serum cortisol. Curve-fitting’s result revealed a characteristic U shape, and 14.0 µg/dL was considered as the cutoff point for serum cortisol. The results of univariate and multivariate logistic regression analyses suggested that when trisecting the serum cortisol level into three parts, the low and high levels of serum cortisol could significantly affect the occurrence of false lumen partial thrombosis compared with the middle level. The odds ratio value of the low and high levels of serum cortisol was 6.12 and 4.65, respectively, in the univariate analysis, and 24.32 and 3.93, respectively, in the multivariate analysis. Low or high levels of serum cortisol might influence the natural result of uTBAD through affecting the false lumen thrombosis.
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影响因子：
1.2
作者：
Nagaoka, Kazuhiro;Sadamatsu, Kenji;Tashiro, Hideki
通讯作者：
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影响因子：
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作者：
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作者：
BARTH, JD;JANSEN, H;BIRKENHAGER, JC
通讯作者：
BIRKENHAGER, JC