Seasonal variation in serum metabolites of northern European dogs.
Seasonal variation in serum metabolites of northern European dogs.
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DOI：
10.1111/jvim.16298
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发表时间：
2022-01
影响因子：
2.6
通讯作者：
Mellanby RJ
中科院分区：
文献类型：
--
作者：
Walker HK;Ottka C;Lohi H;Handel I;Clements DN;Gow AG;Mellanby RJ
代谢分析可识别人类血清代谢物的季节性变化。尽管存在季节性疾病模式，但没有研究评估狗的血清代谢是否随季节变化。健康狗的血清代谢物谱存在季节性变化。十八只健康的、客户拥有的狗。一项前瞻性队列研究。在 12 个月的时间内，每月对 18 只健康狗的血清代谢组学特征进行评估。使用犬特异性质子核磁共振波谱平台进行代谢分析，并使用余弦模型研究了 98 种代谢物的季节性影响。计算了季节性成分，它描述了每种代谢物的季节性变化。我们在 98 种代谢物中的 93 种中没有发现季节性变化的证据。六种代谢物具有统计显着的季节性变化，包括胆固醇（平均 249 mg/dL [6.47 mmol/L]，季节性成分幅度为 9 mg/dL [0.23 mmol/L]；95% 置信区间 [CI] 6‐13 mg/dL [0.14‐0.33 mmol/L]，P < .008），峰值浓度为 6 月份的浓度为 264mg/dL (6.83mmol/L)，12 月份的谷浓度为 236mg/dL (6.12mmol/L)。相比之下，与冬季相比，夏季的乳酸浓度显着降低（平均 20 mg/dL [2.27 mmol/L]，季节性成分幅度为 4 mg/dL [0.42 mmol/L]；95% CI 2‐6 mg/dL [0.22‐0.62 mmol/L]，P < .001）月，峰值浓度为 26 mg/dL 2 月份的浓度为 2.9mmol/L，7 月份的谷浓度为 14mg/dL (1.57mmol/L)。我们没有发现明确的证据表明需要为狗的血清代谢物建立季节性参考范围。
Metabolic profiling identifies seasonal variance of serum metabolites in humans. Despite the presence of seasonal disease patterns, no studies have assessed whether serum metabolites vary seasonally in dogs. There is seasonal variation in the serum metabolite profiles of healthy dogs. Eighteen healthy, client‐owned dogs. A prospective cohort study. Serum metabolomic profiles were assessed monthly in 18 healthy dogs over a 12‐month period. Metabolic profiling was conducted using a canine‐specific proton nuclear magnetic resonance spectroscopy platform, and the effects of seasonality were studied for 98 metabolites using a cosinor model. Seasonal component was calculated, which describes the seasonal variation of each metabolite. We found no evidence of seasonal variation in 93 of 98 metabolites. Six metabolites had statistically significant seasonal variance, including cholesterol (mean 249 mg/dL [6.47 mmol/L] with a seasonal component amplitude of 9 mg/dL [0.23 mmol/L]; 95% confidence interval [CI] 6‐13 mg/dL [0.14‐0.33 mmol/L], P < .008), with a peak concentration of 264 mg/dL (6.83 mmol/L) in June and trough concentration of 236 mg/dL (6.12 mmol/L) in December. In contrast, there was a significantly lower concentration of lactate (mean 20 mg/dL [2.27 mmol/L] with a seasonal component amplitude of 4 mg/dL [0.42 mmol/L]; 95% CI 2‐6 mg/dL [0.22‐0.62 mmol/L], P < .001) during the summer months compared to the winter months, with a peak concentration of 26 mg/dL (2.9 mmol/L) in February and trough concentration of 14 mg/dL (1.57 mmol/L) in July. We found no clear evidence that seasonal reference ranges need to be established for serum metabolites of dogs.
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影响因子：
3.8
作者：
Cao MD;Giskeødegård GF;Bathen TF;Sitter B;Bofin A;Lønning PE;Lundgren S;Gribbestad IS
通讯作者：
Gribbestad IS
影响因子：
4.3
作者：
Dyar KA;Eckel-Mahan KL
通讯作者：
Eckel-Mahan KL
影响因子：
--
作者：
Ockene, IS;Chiriboga, DE;Hebert, JR
通讯作者：
Hebert, JR
影响因子：
1.2
作者：
Ottka, Claudia;Vapalahti, Katariina;Lohi, Hannes
通讯作者：
Lohi, Hannes
影响因子：
37.8
作者：
Shah SH;Kraus WE;Newgard CB
通讯作者：
Newgard CB