Changes in body weight and metabolic risk during time restricted feeding in premenopausal versus postmenopausal women.
Changes in body weight and metabolic risk during time restricted feeding in premenopausal versus postmenopausal women.
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DOI：
10.1016/j.exger.2021.111545
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发表时间：
2021-10-15
影响因子：
3.9
通讯作者：
Varady KA
中科院分区：
文献类型：
--
作者：
Cienfuegos S;Gabel K;Kalam F;Ezpeleta M;Lin S;Varady KA
时间限制喂养（TRF）包括将进食窗口限制在特定的小时数内，并在一天的剩余时间内禁食。本研究检查了TRF期间体重和代谢危险因素的变化在绝经前和绝经后妇女之间是否存在差异。这是在肥胖成人中进行的8周TRF研究（每天4-6小时进食窗口，18-20小时空腹窗口）的次要分析。男性受试者被排除在外，女性受试者根据月经状态分为两组：绝经前（n = 13）或绝经后（n = 19）。围绝经期妇女被排除在原始研究之外。绝经前女性（−3.3 ± 0.4%）和绝经后女性（−3.3 ± 0.5%）在第8周时体重下降（时间的主要效应，P < 0.001），组间无差异（无组×时间相互作用）。两组的依从性均极佳，绝经前女性遵守规定的进食时间窗为6.2 ± 0.1天/周，绝经后女性遵守规定的进食时间窗为6.2 ± 0.2天/周。两组的脂肪量、瘦体重、空腹胰岛素、胰岛素抵抗和8-异前列腺素（氧化应激的标志物）的减少相似（时间的主要影响，所有比较P < 0.05）。到第8周，两组的内脏脂肪量、相对骨骼肌指数（RSMI）、血压、LDL胆固醇、HDL胆固醇、甘油三酯、空腹血糖、HbA 1c、TNF-α和IL-6保持不变。这些发现表明，TRF的体重减轻和代谢益处在绝经前和绝经后肥胖妇女之间没有差异。
Time restricted feeding (TRF) involves confining the eating window to a specific number of hours, and fasting for the remaining hours of the day. This study examined if changes in body weight and metabolic risk factors during TRF, differ between premenopausal and postmenopausal women. This is a secondary analysis of an 8-week TRF study (4–6 h eating window, 18–20 h fasting window daily) conducted in adults with obesity. Male participants were excluded, and female subjects were classified in two groups based on menstrual status: premenopausal (n = 13), or postmenopausal (n = 19). Perimenopausal women were excluded from the original study. Body weight decreased by week 8 in premenopausal women (−3.3 ± 0.4%) and postmenopausal women (−3.3 ± 0.5%) (main effect of time, P < 0.001), with no difference between groups (no group × time interaction). Adherence was excellent in both groups, with premenopausal women adhering to their prescribed eating window on 6.2 ± 0.1 d/week, and postmenopausal women adhering to their window on 6.2 ± 0.2 d/week. Fat mass, lean mass, fasting insulin, insulin resistance, and 8-isoprostane (marker of oxidative stress) were reduced similarly in both groups (main effect of time, P < 0.05 for all comparisons). Visceral fat mass, relative skeletal muscle index (RSMI), blood pressure, LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose, HbA1c, TNF-alpha and IL-6 remained unchanged in both groups by week 8. These findings suggest that the weight loss and metabolic benefits of TRF do not differ between premenopausal and postmenopausal women with obesity.
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影响因子：
2.7
作者：
Gayoso-Diz P;Otero-González A;Rodriguez-Alvarez MX;Gude F;García F;De Francisco A;Quintela AG
通讯作者：
Quintela AG
影响因子：
120.7
作者：
Solomon, CG;Hu, FB;Manson, JE
通讯作者：
Manson, JE
影响因子：
120.7
作者：
Gardner, Christopher D.;Kiazand, Alexandre;King, Abby C.
通讯作者：
King, Abby C.
影响因子：
4.9
作者：
Lovejoy, J. C.;Champagne, C. M.;Smith, S. R.
通讯作者：
Smith, S. R.
DOI：
10.3109/13697137.2011.650656
发表时间：
2012-04
期刊：
Climacteric : the journal of the International Menopause Society
影响因子：
--
作者：
Harlow SD;Gass M;Hall JE;Lobo R;Maki P;Rebar RW;Sherman S;Sluss PM;de Villiers TJ;STRAW+10 Collaborative Group
通讯作者：
STRAW+10 Collaborative Group