Rest but busy: Aberrant resting-state functional connectivity of triple network model in insomnia.
Rest but busy: Aberrant resting-state functional connectivity of triple network model in insomnia.
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休息但忙碌：失眠中三重网络模型的异常静息状态功能连接
DOI：
10.1002/brb3.876
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发表时间：
2018-03
影响因子：
3.1
通讯作者：
Lei X
中科院分区：
文献类型：
--
作者：
Dong X;Qin H;Wu T;Hu H;Liao K;Cheng F;Gao D;Lei X
在解释失眠障碍(ID)的病因和维持的众多模型中，一个经典的假说是过度唤醒。静息状态的大规模脑网络之间的异常功能连接可能是这一假说的潜在神经学机制。本研究旨在探讨失眠障碍(ID)患者静息状态下大规模脑网络之间的功能网络连接(FNC)。本研究采用静息状态功能磁共振成像技术，观察ID患者的背侧注意网络(DAN)、额顶控制网络(FPC)、前默认模式网络(ADMN)、后默认模式网络(PDMN)是否存在FNC异常，并与正常睡眠者(HGSS)进行比较。采用皮尔逊相关分析探讨ID患者的FNC异常是否与睡眠参数、认知和情绪评分以及问卷和任务评估的行为表现有关。用思维控制能力问卷(TCAQ)测评的ID患者主观思维控制能力较HGSS患者差，负性情绪较HGSS患者多。有趣的是，相对于HGSS，ID患者在DAN和FPC之间的FNC显著增加，而在ADMN和PDMN之间FNC显著降低。对ID患者的探索性分析显示，DAN-FPC FNC与精神运动警戒任务(PVT)的反应时(RT)呈显著正相关。目前的研究表明，即使在休息状态下，失眠症患者任务激活和任务去激活的大规模脑网络仍可能保持高度觉醒状态，看起来与有外部刺激的任务条件下的模式非常相似。这些结果支持失眠的高觉醒模型。
One classical hypothesis among many models to explain the etiology and maintenance of insomnia disorder (ID) is hyperarousal. Aberrant functional connectivity among resting‐state large‐scale brain networks may be the underlying neurological mechanisms of this hypothesis. The aim of current study was to investigate the functional network connectivity (FNC) among large‐scale brain networks in patients with insomnia disorder (ID) during resting state. In the present study, the resting‐state fMRI was used to evaluate whether patients with ID showed aberrant FNC among dorsal attention network (DAN), frontoparietal control network (FPC), anterior default mode network (aDMN), and posterior default mode network (pDMN) compared with healthy good sleepers (HGSs). The Pearson's correlation analysis was employed to explore whether the abnormal FNC observed in patients with ID was associated with sleep parameters, cognitive and emotional scores, and behavioral performance assessed by questionnaires and tasks. Patients with ID had worse subjective thought control ability measured by Thought Control Ability Questionnaire (TCAQ) and more negative affect than HGSs. Intriguingly, relative to HGSs, patients with ID showed a significant increase in FNC between DAN and FPC, but a significant decrease in FNC between aDMN and pDMN. Exploratory analysis in patients with ID revealed a significantly positive correlation between the DAN‐FPC FNC and reaction time (RT) of psychomotor vigilance task (PVT). The current study demonstrated that even during the resting state, the task‐activated and task‐deactivated large‐scale brain networks in insomniacs may still maintain a hyperarousal state, looking quite similar to the pattern in a task condition with external stimuli. Those results support the hyperarousal model of insomnia.
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影响因子：
2.6
作者：
Chen, Michael C.;Chang, Catie;Glover, Gary H.;Gotlib, Ian H.
通讯作者：
Gotlib, Ian H.
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
De Havas, Jack A.;Parimal, Sarayu;Chee, Michael W. L.
通讯作者：
Chee, Michael W. L.
影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.
影响因子：
5.7
作者：
Cole, Michael W.;Schneider, Walter
通讯作者：
Schneider, Walter