Baseline hippocampal beta band power is lower in the presence of movement uncertainty.
Baseline hippocampal beta band power is lower in the presence of movement uncertainty.
复制标题
在运动不确定性的存在下，基线海马β带功率较低。
DOI：
10.1088/1741-2552/ac7fb9
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发表时间：
2022-07-22
影响因子：
4
通讯作者：
Lee, Brian
中科院分区：
文献类型：
--
作者：
Gilbert, Zachary D.;Martin Del Campo-Vera, Roberto;Tang, Austin M.;Chen, Kuang-Hsuan;Sebastian, Rinu;Shao, Arthur;Tabarsi, Emiliano;Chung, Ryan S.;Leonor, Andrea;Sundaram, Shivani;Heck, Christi;Nune, George;Liu, Charles Y.;Kellis, Spencer;Lee, Brian
关键词：
这项研究旨在通过测量运动提示前一段时间的β波段功率来表征不确定的海马神经特征。在癫痫患者的大脑中植入海马区深度电极，以进行立体脑电监测。在运动任务，如直达(DR)和去/不去(GNG)任务中，观察到了海马β(13-30赫兹)功率的变化。这两个任务之间的主要区别在于是否应该执行移动的不确定性。先前关于大脑皮层对不确定性的反应的研究发现，基线的β能力会随着不确定性的变化而变化。在DR和GNG任务的整个阶段都采集了SEEG数据。使用Wilcoxon秩和检验比较DR和GNG任务在固定阶段的β频带功率。这项不配对的测试也被用来分析任务之间从线索到任务完成的反应时间。在这项研究中，分析了8名同时执行两种到达任务的患者。GNG任务中的移动响应时间比DR任务中的平均慢210毫秒。与DR任务相比，所有患者在GNG任务中的反应潜伏期都显著延长(Wilcoxon秩和p值：0.001)。在GNG和DR任务的固定阶段，8名患者中有6名患者在单一海马区接触的β功率显示出统计学上的显著差异。在组水平上，GNG任务的基线β功率显著低于DR任务(Wilcoxon秩和p值0.001)。这项新的研究发现，在存在任务不确定性的情况下，海马体中的基线贝塔能力低于没有任务不确定性的情况。这一发现表明，在运动准备过程中，运动不确定性是影响基线海马区β能力的一个重要因素。
This study aimed to characterize hippocampal neural signatures of uncertainty by measuring beta band power in the period prior to movement cue. Participants with epilepsy were implanted with hippocampal depth electrodes for stereo electroencephalographic (SEEG) monitoring. Hippocampal beta (13–30 Hz) power changes have been observed during motor tasks such as the direct reach (DR) and Go/No-Go (GNG) tasks. The primary difference between the tasks is the presence of uncertainty about whether movement should be executed. Previous research on cortical responses to uncertainty has found that baseline beta power changes with uncertainty. SEEG data were sampled throughout phases of the DR and GNG tasks. Beta-band power during the fixation phase was compared between the DR and GNG task using a Wilcoxon rank sum test. This unpaired test was also used to analyze response times from cue to task completion between tasks. Eight patients who performed both reaching tasks were analyzed in this study. Movement response times in the GNG task were on average 210 milliseconds slower than in the DR task. All patients exhibited a significantly increased response latency in the GNG task compared to the DR task (Wilcoxon rank-sum p-value < 0.001). Six out of eight patients demonstrated statistically significant differences in beta power in single hippocampal contacts between the fixation phases of the GNG and DR tasks. At the group level, baseline beta power was significantly lower in the GNG task than in the DR task (Wilcoxon rank-sum p-value < 0.001). This novel study found that, in the presence of task uncertainty, baseline beta power in the hippocampus is lower than in its absence. This finding implicates movement uncertainty as an important factor in baseline hippocampal beta power during movement preparation.
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影响因子：
4.4
作者：
Haukoos, JS;Lewis, RJ
通讯作者：
Lewis, RJ
影响因子：
3.2
作者：
Fan J;Van Dam NT;Gu X;Liu X;Wang H;Tang CY;Hof PR
通讯作者：
Hof PR
DOI：
10.1111/ner.13486
发表时间：
2022-03
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Del Campo-Vera RM;Tang AM;Gogia AS;Chen KH;Sebastian R;Gilbert ZD;Nune G;Liu CY;Kellis S;Lee B
通讯作者：
Lee B
影响因子：
3.7
作者：
Burman, Douglas D.
通讯作者：
Burman, Douglas D.
影响因子：
3.4
作者：
Klostermann, Fabian;Nikulin, Vadim V.;Curio, Gabriel
通讯作者：
Curio, Gabriel