Population-based case-control study of the association between weather-related extreme heat events and neural tube defects.
Population-based case-control study of the association between weather-related extreme heat events and neural tube defects.
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DOI：
10.1002/bdr2.1086
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发表时间：
2017-11-01
影响因子：
2.1
通讯作者：
National Birth Defects Prevention Study
中科院分区：
文献类型：
--
作者：
Soim A;Lin S;Sheridan SC;Hwang SA;Hsu WH;Luben TJ;Shaw GM;Feldkamp ML;Romitti PA;Reefhuis J;Langlois PH;Browne ML;National Birth Defects Prevention Study
在动物研究中，身体核心温度升高已被证明具有致畸作用。我们的研究评估了夏季与天气相关的极端高温事件（EHEs）与神经管缺陷（NTDs）之间的关联，并进一步调查了孕前体重指数（BMI）高的孕妇是否比BMI正常的孕妇有更大的风险生下与暴露于EHE相关的NTDs。我们在NTD婴儿的母亲和无重大出生缺陷婴儿的母亲中进行了一项以人群为基础的病例对照研究，这些婴儿参加了国家出生缺陷预防研究，并在夏季怀孕后第三或第四周至少有一天。EHE是使用每日最高普遍表观温度的第95和第90个单位来定义的。调整后的比值比和95%置信区间采用Firth惩罚似然法的无条件logistic回归模型计算，同时控制其他已知的风险因素。总体而言，我们没有观察到EHE和NTD之间的显着关联。在气候区域水平上，在纽约（东北部）、北卡罗来纳州和格鲁吉亚（东南部）以及爱荷华州（上中西部）观察到EHE 95的持续升高但统计上不显著的估计值。未观察到BMI的影响改变。在胚胎发生的相关发育窗口期间发生的EHE似乎不会明显影响NTD的风险。未来的研究应完善暴露评估，并更全面地考虑可能改变天气暴露影响的母亲活动。
Elevated body core temperature has been shown to have teratogenic effects in animal studies. Our study evaluated the association between weather-related extreme heat events (EHEs) in the summer season and neural tube defects (NTDs), and further investigated whether pregnant women with a high pre-gestational body mass index (BMI) have a greater risk of having a child with NTDs associated with exposure to EHE than women with a normal BMI. We conducted a population-based case-control study among mothers of infants with NTDs and mothers of infants without major birth defects, who participated in the National Birth Defects Prevention Study and had at least one day of the third or fourth week post-conception during summer months. EHEs were defined using the 95th and the 90th percentiles of the daily maximum universal apparent temperature. Adjusted odds ratios and 95% confidence intervals were calculated using unconditional logistic regression models with Firth’s penalized likelihood method while controlling for other known risk factors. Overall, we did not observe a significant association between EHEs and NTDs. At the climate region level, consistently elevated but not statistically significant estimates were observed for EHE95 in New York (Northeast), North Carolina and Georgia (Southeast), and Iowa (Upper Midwest). No effect modification by BMI was observed. EHEs occurring during the relevant developmental window of embryogenesis do not appear to appreciably affect the risk of NTDs. Future studies should refine exposure assessment, and more completely account for maternal activities that may modify the effects of weather exposure.
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影响因子：
7.1
作者：
Savastano, David M.;Gorbach, Alexander M.;Yanovski, Jack A.
通讯作者：
Yanovski, Jack A.
影响因子：
10.4
作者：
Anderson GB;Bell ML
通讯作者：
Bell ML
影响因子：
10.4
作者：
Auger N;Fraser WD;Sauve R;Bilodeau-Bertrand M;Kosatsky T
通讯作者：
Kosatsky T
影响因子：
5
作者：
Cogswell, Mary E.;Bitsko, Rebecca H.;Reefhuis, Jennita
通讯作者：
Reefhuis, Jennita
DOI：
10.1002/bdra.23113
发表时间：
2013-02-01
影响因子：
--
作者：
McMahon, Daria M.;Liu, Jihong;Best, Robert G.
通讯作者：
Best, Robert G.