Downregulation of 5‐HT1A receptors in rat hypothalamus and dentate gyrus after “binge” pattern cocaine administration
Downregulation of 5‐HT1A receptors in rat hypothalamus and dentate gyrus after “binge” pattern cocaine administration
复制标题
“暴饮”模式可卡因给药后大鼠下丘脑和齿状回 5-HT1A 受体的下调
作者：
G. Perret;J. Schluger;E. Unterwald;J. Kreuter;A. Ho;M. Kreek
在定量放射自显影研究中，使用选择性5-HT 1A受体激动剂[3H] 8-羟基-2-（二-N-丙基氨基）四氢萘（8-OH-DPAT）和5-HT 2A受体拮抗剂[3H]酮色林作为氚化配体，研究了慢性可卡因暴露对大鼠中枢多巴胺能系统的影响。大鼠以"狂欢"模式给予可卡因，15 mg/kg/注射，每天三次，间隔1 h，持续14天，以模仿人类可卡因成瘾者中常见的模式。与注射生理盐水的大鼠相比，在给予可卡因的大鼠的腹内侧下丘脑（P <0.001）和背侧齿状回（P <0.01）中发现[3H] 8-OH-DPAT的结合显著降低。在额叶、顶叶、无颗粒岛叶和梨状皮质、尾壳核、嗅结节、丘脑、隔海马核和屏状核中未发现[3H]酮色林结合的显著差异。一些研究表明，5-HT1A受体激动剂具有抗抑郁特性。在动物模型中的其他研究表明，5-HT1A受体激动剂刺激下丘脑-垂体-肾上腺轴，这是令人感兴趣的，因为该轴的慢性激活与焦虑和抑郁有关。我们的数据表明，在动物模型中，慢性"狂欢"模式可卡因给药后，肾上腺素能系统的5-HT 1A组分发生改变，可能与HPA轴和行为的变化有关。Synapse 30：166 - 171，1998.© 1998 Wiley利斯公司
The effect of chronic cocaine exposure on the central serotonergic system in the rat was investigated using a selective 5‐HT1A receptor agonist, [3H]8‐hydroxy‐2‐(di‐N‐propylamino) tetralin (8‐OH‐DPAT), and a 5‐HT2A receptor antagonist, [3H]ketanserin, as tritiated ligands in a quantitative autoradiography study. Rats were administered cocaine in a “binge” pattern, 15 mg/kg/injection, three times a day, at 1‐h intervals for 14 days to mimic the pattern often seen in human cocaine addicts. A significant decrease in the binding of [3H]8‐OH‐DPAT was found in the ventromedial hypothalamus (P < 0.001) and the dorsal dentate gyrus (P < 0.01) in rats administered cocaine as compared with rats injected with saline. No significant difference in the binding of [3H]ketanserin was found in frontal, parietal, agranular insular, and piriform cortices, caudate‐putamen, olfactory tubercle, nucleus accumbens, thalamus, septohippocampal nucleus, and claustrum. Several studies have shown that 5‐HT1A receptor agonists have antidepressant properties. Other studies, in animal models, have shown that 5‐HT1A receptor agonists stimulate the hypothalamic–pituitary–adrenal axis, which is of interest, since chronic activation of this axis has been related to anxiety and depression. Our data show that the 5‐HT1A component of the serotonergic system is altered following chronic “binge” pattern cocaine administration in an animal model and may be related to changes in the HPA axis and behavior. Synapse 30:166–171, 1998. © 1998 Wiley‐Liss, Inc.
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DOI：
10.1016/0169-328x(92)90178-e
发表时间：
1992-07-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
BRANCH, AD;UNTERWALD, EM;KREEK, MJ
通讯作者：
KREEK, MJ
放射自显影分析约束诱导的应激对雄性和雌性大鼠背侧海马 5-HT1A、5-HT1C 和 5-HT2 受体的影响。
影响因子：
4.1
作者：
Mendelson,SD;McEwen,BS
通讯作者：
McEwen,BS
影响因子：
5
作者：
M. Owens;E. Edwards;C. Nemeroff
通讯作者：
M. Owens;E. Edwards;C. Nemeroff
大鼠无限量静脉注射可卡因戒断期间伏隔核中的血清素功能障碍。
DOI：
--
发表时间：
1995
期刊：
The Journal of pharmacology and experimental therapeutics.
影响因子：
--
作者：
Parsons,LH;Koob,GF;Weiss,F
通讯作者：
Weiss,F
影响因子：
56.9
作者：
GAWIN, FH
通讯作者：
GAWIN, FH