Carotid Intima-Media Thickness Is Associated With Premature Parental Coronary Heart Disease: The Framingham Heart Study
Carotid Intima-Media Thickness Is Associated With Premature Parental Coronary Heart Disease: The Framingham Heart Study
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颈动脉内膜中层厚度与早产儿父母冠心病相关：弗雷明汉心脏研究
DOI：
10.1161/01.cir.0000081764.35431.de
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
C. O’Donnell
中科院分区：
文献类型：
--
作者：
Thomas J. Wang;B. Nam;R. D'Agostino;P. Wolf;D. Lloyd‐Jones;C. Macrae;P. Wilson;J. Polak;C. O’Donnell
冠心病家族史是心血管事件的独立危险因素。然而，这种易感性的机制尚未完全阐明。我们假设冠心病家族易感性的一个重要因素是亚临床动脉粥样硬化，它可以通过非侵入性成像检测到。方法和结果--我们研究了1662名在Fragmentary Offspring研究中接受颈动脉超声检查的受试者（平均年龄57岁，51%为女性），这些受试者的亲生父母都在原始队列中。父母CHD事件由医生终点委员会前瞻性验证。在年龄和多变量校正分析中，研究了颈动脉内膜中层厚度（IMT）与父母早发CHD（发生在60岁之前）和任何父母CHD（无年龄限制）的关系。父母中至少有一方患有早发冠心病的受试者的颈内动脉IMT均值高于父母中无早发冠心病病史的受试者（男性1.13 mm vs 1.04 mm，P <0.01;女性0.92 mm vs 0.85 mm，P =0.03）。在两种性别中，这些差异在调整心血管危险因素后仍然显着。在不限制父母CHD发病年龄的分析中，颈动脉IMT与父母CHD之间的相关性无统计学意义。颈总动脉IMT与早产儿或任何父母CHD也没有显著相关性。结论：这些发现表明，在颈动脉中评估的亚临床动脉粥样硬化在有冠心病家族史的个体中更为普遍。特别是早发性父母CHD，其后代具有很强的动脉粥样硬化家族易感性。
Background—A family history of coronary heart disease (CHD) is an independent risk factor for cardiovascular events. However, the mechanisms underlying this susceptibility have not been fully elucidated. We hypothesized that an important mediator of the familial predisposition to CHD is subclinical atherosclerosis, which is detectable by noninvasive imaging. Methods and Results—We studied 1662 subjects (mean age 57, 51% women) in the Framingham Offspring Study who underwent carotid ultrasonography and had both biological parents in the original (parental) cohort. Parental CHD events were validated prospectively by a physician endpoint committee. The associations of carotid intima-media thickness (IMT) with premature parental CHD (occurring before age 60) and any parental CHD (no age restriction) were examined in age- and multivariable-adjusted analyses. Age-adjusted mean internal carotid IMT was higher in subjects who had at least one parent with premature CHD than in those without a validated parental history of premature CHD (men 1.13 versus 1.04 mm, P <0.01; women 0.92 versus 0.85 mm, P =0.03). In both sexes, these differences remained significant after adjustment for cardiovascular risk factors. In analyses without a restriction on parental age of CHD onset, the association between carotid IMT and parental CHD was not statistically significant. There was also no significant association of common carotid IMT with premature or any parental CHD. Conclusions—These findings suggest that subclinical atherosclerosis, assessed in the carotid arteries, is more prevalent in individuals with a family history of CHD. Early-onset parental CHD, in particular, identifies offspring with a strong familial predisposition to atherosclerosis.
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影响因子：
2.8
作者：
SCHILDKRAUT, JM;MYERS, RH;KANNEL, WB
通讯作者：
KANNEL, WB
影响因子：
8.3
作者：
BURKE, GL;EVANS, GW;HEISS, G
通讯作者：
HEISS, G
影响因子：
4.8
作者：
MYERS, RH;KIELY, DK;KANNEL, WB
通讯作者：
KANNEL, WB
影响因子：
37.8
作者：
Friedlander, Y;Siscovick, DS;Cobb, LA
通讯作者：
Cobb, LA
影响因子：
158.5
作者：
O'Leary, DH;Polak, JF;Wolfson, SK
通讯作者：
Wolfson, SK