Lifting gate polydimethylsiloxane microvalves and pumps for microfluidic control.
Lifting gate polydimethylsiloxane microvalves and pumps for microfluidic control.
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DOI：
10.1021/ac202934x
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发表时间：
2012-02-21
影响因子：
7.4
通讯作者：
Mathies, Richard A.
中科院分区：
文献类型：
--
作者：
Kim, Jungkyu;Kang, Minjee;Jensen, Erik C.;Mathies, Richard A.
我们描述了气动“提升闸”微阀和微泵的开发及特性。包含闸结构的流体层和气动层通过聚二甲基硅氧烷（PDMS）软光刻技术制造，并通过氧等离子体处理永久键合。然后，微阀结构可逆地键合到无特征的玻璃或塑料基底上，形成玻璃 - PDMS和塑料 - PDMS混合微通道结构。随着关闭压力的增加，微阀的突破压力线性增加，最高可达65 kPa。这些结构的泵送能力根据所采用的循环次数和关闭压力，范围从纳升至微升。从流速测量来看，微泵结构的泵送效率高达86.2%。通过进行自动免疫分析，证明了这些结构在集成样品处理方面的实用性。这些提升闸阀和泵结构能够方便地将复杂的微流体控制系统与多种芯片实验室基底集成。
We describe the development and characterization of pneumatically actuated “lifting gate” microvalves and pumps. A fluidic layer containing the gate structure and a pneumatic layer are fabricated by soft-lithography in PDMS and bonded permanently with an oxygen plasma treatment. The microvalve structures are then reversibly bonded to a featureless glass or plastic substrate to form hybrid glass-PDMS and plastic-PDMS microchannel structures. The breakthrough pressures of the microvalve increase linearly up to 65 kPa as the closing pressure increases. The pumping capability of these structures ranges from the nanoliter to microliter scale depending on the number of cycles and closing pressure employed. The micropump structures exhibit up to 86.2% pumping efficiency from flow rate measurements. The utility of these structures for integrated sample processing is demonstrated by performing an automated immunoassay. These lifting gate valve and pump structures enable facile integration of complex microfluidic control systems with a wide range of lab-on-a-chip substrates.
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影响因子：
56.9
作者：
Unger, MA;Chou, HP;Quake, SR
通讯作者：
Quake, SR
影响因子：
6.1
作者：
Zaytseva, NV;Goral, VN;Baeumner, AJ
通讯作者：
Baeumner, AJ
用于一次性微流体的 PMMA/PDMS 阀门和泵
影响因子：
6.1
作者：
Zhang, Wenhua;Lin, Shuichao;Yang, Chaoyong James
通讯作者：
Yang, Chaoyong James
影响因子：
8.4
作者：
Grover, WH;Skelley, AM;Mathies, RA
通讯作者：
Mathies, RA
DOI：
10.1073/pnas.0604663103
发表时间：
2006-12-19
影响因子：
11.1
作者：
Easley, Christopher J.;Karlinsey, James M.;Landers, James P.
通讯作者：
Landers, James P.