Do physical activity and aerobic fitness moderate the association between birth weight and metabolic risk in youth?: the European Youth Heart Study.
Do physical activity and aerobic fitness moderate the association between birth weight and metabolic risk in youth?: the European Youth Heart Study.
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DOI：
10.2337/dc10-1178
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发表时间：
2011-01
期刊：
影响因子：
16.2
通讯作者：
Ekelund U
中科院分区：
文献类型：
--
作者：
Ridgway CL;Brage S;Anderssen SA;Sardinha LB;Andersen LB;Ekelund U
出生体重较低与代谢疾病的风险较高有关。这项研究的目的是检查身体活动和有氧健身是否可以改变出生体重和代谢风险之间的关联。欧洲青年心脏研究是一项基于人群的研究，研究对象为9岁和15奥尔兹的青少年（n = 1，254）。母亲报告出生体重。皮肤褶皱测量用于计算体脂和脂肪质量指数（FMI =脂肪质量[千克]/身高2）。使用空腹血液样本测量胰岛素。使用臀部佩戴的加速度计（MTI Actigraph）测量身体活动，>600分钟/天，持续≥3天，并表示为“平均活动”（每分钟计数）和中等强度以上活动（>2000 cpm）所花费的时间。有氧健身评估使用最大自行车测力计测试（瓦特每公斤无脂肪质量）。高出生体重与高FMI（β = 0.49 [95%CI 0.21-0.80]; P = 0.001）和高腰围（0.90 [0.32-1.47]; P < 0.001）相关，校正了性别、年龄组、性成熟度、身高和社会经济地位。只有在进一步校正青少年腰围和身高后，出生体重较低与空腹胰岛素较高相关（-0.059 [-0.107至-0.011]; P = 0.016）。没有证据表明在调整身体活动或有氧健身后，这种关联有任何改变。目前的研究没有发现任何证据表明体育活动或有氧健身可以缓和健康儿童和青少年中较高的出生体重和脂肪量增加以及较大的腰围或较低的出生体重与胰岛素抵抗之间的关联。
Lower birth weight has been associated with a greater risk of metabolic diseases. The aim of this study was examine whether physical activity and aerobic fitness may modify associations between birth weigh and metabolic risk. The European Youth Heart Study is a population-based study of 9 and 15 year olds (n = 1,254). Birth weight was maternally reported. Skin fold measures were used to calculate body fat and fat mass index (FMI = fat mass [kilograms]/height2). Insulin was measured using fasting blood samples. Physical activity was measured using a hip-worn accelerometer (MTI Actigraph) for >600 min/day for ≥3 days and is expressed as “average activity” (counts per minute) and time spent in above moderate intensity activity (>2000 cpm). Aerobic fitness was assessed using a maximal cycle ergometry test (watts per kilogram fat-free mass). Higher birth weight was associated with higher FMI (β = 0.49 [95% CI 0.21–0.80]; P = 0.001) and greater waist circumference (0.90 [0.32–1.47]; P < 0.001), adjusted for sex, age-group, sexual maturity, height, and socioeconomic status. Lower birth weight was associated with higher fasting insulin only after further adjustment for adolescent waist circumference and height (−0.059 [−0.107 to −0.011]; P = 0.016). There was no evidence for any modification of the associations after adjustment for physical activity or aerobic fitness. The present study did not find any evidence that physical activity or aerobic fitness can moderate the associations among higher birth weight and increased fat mass and greater waist circumference or between lower birth weight and insulin resistance in healthy children and adolescents.
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DOI：
10.1111/j.1471-0528.2008.01717.x
发表时间：
2008-06
期刊：
BJOG : an international journal of obstetrics and gynaecology
影响因子：
--
作者：
Adegboye AR;Heitmann B
通讯作者：
Heitmann B
DOI：
10.1249/01.mss.0000185657.86065.98
发表时间：
2005-11-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Trost, SG;McIver, KL;Pate, RR
通讯作者：
Pate, RR
影响因子：
2.8
作者：
Eriksson, Marit;Tynelius, Per;Rasmussen, Finn
通讯作者：
Rasmussen, Finn
影响因子：
7.1
作者：
Elia, Marinos;Betts, Peter;Mulligan, Jean
通讯作者：
Mulligan, Jean
影响因子：
5.1
作者：
Eriksson, JG;Ylihärsilä, H;Barker, DJP
通讯作者：
Barker, DJP