Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length.
Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length.
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DOI：
10.1016/j.physbeh.2011.11.016
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发表时间：
2012-04-12
影响因子：
2.9
通讯作者：
Epel, Elissa
中科院分区：
文献类型：
--
作者：
Tomiyama, A. Janet;O'Donovan, Aoife;Lin, Jue;Puterman, Eli;Lazaro, Alanie;Chan, Jessica;Dhabhar, Firdaus S.;Wolkowitz, Owen;Kirschbaum, Clemens;Blackburn, Elizabeth;Epel, Elissa
长期暴露于压力及其生理介质，特别是皮质醇，可能会导致端粒维持受损。在这项研究中，我们检查了对急性应激源的更大皮质醇反应和/或每日皮质醇分泌失调模式是否与较短的端粒长度相关。 23 名绝经后妇女，包括痴呆症伴侣的照顾者 (n = 14) 和年龄和体重指数匹配的非照顾者，在醒来时、醒来后 30 分钟和就寝时提供了皮质醇唾液样本的家庭采样，并收集了 12 小时的过夜尿液。他们还暴露在急性实验室压力源下，并在整个过程中提供唾液样本。从空腹血样中分离外周血单核细胞并测定端粒长度。正如假设的那样，皮质醇对急性应激源的反应越大，端粒越短，夜间尿中游离皮质醇水平越高，白天皮质醇斜率越平坦。虽然对急性应激的强烈生理反应具有重要功能，但频繁的高应激反应的长期后果可能包括端粒加速缩短。
Long-term exposure to stress and its physiological mediators, in particular cortisol, may lead to impaired telomere maintenance. In this study, we examine if greater cortisol responses to an acute stressor and/or dysregulated patterns of daily cortisol secretion are associated with shorter telomere length. Twenty-three post-menopausal women comprising caregivers for dementia partners (n=14) and age- and BMI-matched non-caregivers provided home sampling of cortisol–saliva samples at waking, 30 min after waking, and bedtime, and a 12-hour overnight urine collection. They were also exposed to an acute laboratory stressor throughout which they provided saliva samples. Peripheral blood mononuclear cells were isolated from a fasting blood sample and assayed for telomere length. As hypothesized, greater cortisol responses to the acute stressor were associated with shorter telomeres, as were higher overnight urinary free cortisol levels and flatter daytime cortisol slopes. While robust physiological responses to acute stress serve important functions, the long-term consequences of frequent high stress reactivity may include accelerated telomere shortening.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
3.2
作者：
KIRSCHBAUM, C;PIRKE, KM;HELLHAMMER, DH
通讯作者：
HELLHAMMER, DH
影响因子：
15.1
作者：
Choi, Jenny;Fauce, Steven R.;Effros, Rita B.
通讯作者：
Effros, Rita B.
影响因子：
14.9
作者：
Cawthon, RM
通讯作者：
Cawthon, RM
DOI：
10.1073/pnas.0605053103
发表时间：
2006-11-07
影响因子：
11.1
作者：
Adam, Emma K.;Hawkley, Louise C.;Cacioppo, John T.
通讯作者：
Cacioppo, John T.