White matter integrity supports BOLD signal variability and cognitive performance in the aging human brain.
White matter integrity supports BOLD signal variability and cognitive performance in the aging human brain.
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DOI：
10.1371/journal.pone.0120315
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Kramer AF
中科院分区：
文献类型：
--
作者：
Burzynska AZ;Wong CN;Voss MW;Cooke GE;McAuley E;Kramer AF
老年人认知能力的下降与灰质（GM）的次优神经处理和白质（WM）的完整性降低有关，但对全脑结构-功能-认知的关联仍然知之甚少。在这里，我们应用了一种新的测量GM处理的方法——血氧水平依赖信号（SDBOLD）的时刻变化——来研究91名健康老年人（60-80岁）静息状态下GM功能、四个主要认知领域的表现（即流体智力、感知速度、情景记忆、词汇）和WM微观结构完整性之间的关系。我们使用多元偏最小二乘分析建模了全gm SDBOLD与认知表现之间的关系。我们发现，更大的SDBOLD与更好的流体能力和记忆力有关。大多数显示与行为相关的SDBOLD区域（如楔前叶和脑岛）定位于连接和整合大脑中分离功能域的网络间或网络内“枢纽”。我们的研究结果表明，中枢区域神经处理的最佳动态范围可能支持特别依赖于最灵活的神经处理和不同大脑网络之间复杂的串扰的认知操作。最后，我们证明所有主要脑区脑区完整性更高的老年人也有更高的SDBOLD，在记忆和流体能力测试中表现更好。我们得出结论，sdold是健康老年人认知个体差异的一个有希望的功能性神经关联，并得到了整体WM完整性的支持。
Decline in cognitive performance in old age is linked to both suboptimal neural processing in grey matter (GM) and reduced integrity of white matter (WM), but the whole-brain structure-function-cognition associations remain poorly understood. Here we apply a novel measure of GM processing–moment-to-moment variability in the blood oxygenation level-dependent signal (SDBOLD)—to study the associations between GM function during resting state, performance on four main cognitive domains (i.e., fluid intelligence, perceptual speed, episodic memory, vocabulary), and WM microstructural integrity in 91 healthy older adults (aged 60-80 years). We modeled the relations between whole-GM SDBOLD with cognitive performance using multivariate partial least squares analysis. We found that greater SDBOLD was associated with better fluid abilities and memory. Most of regions showing behaviorally relevant SDBOLD (e.g., precuneus and insula) were localized to inter- or intra-network “hubs” that connect and integrate segregated functional domains in the brain. Our results suggest that optimal dynamic range of neural processing in hub regions may support cognitive operations that specifically rely on the most flexible neural processing and complex cross-talk between different brain networks. Finally, we demonstrated that older adults with greater WM integrity in all major WM tracts had also greater SDBOLD and better performance on tests of memory and fluid abilities. We conclude that SDBOLD is a promising functional neural correlate of individual differences in cognition in healthy older adults and is supported by overall WM integrity.
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DOI：
10.1073/pnas.0901831106
发表时间：
2009-06-23
影响因子：
11.1
作者：
Deco, Gustavo;Jirsa, Viktor;Koetter, Rolf
通讯作者：
Koetter, Rolf
影响因子：
4.9
作者：
CATTELL, RB
通讯作者：
CATTELL, RB
影响因子：
19.6
作者：
Colizza, V;Flammini, A;Vespignani, A
通讯作者：
Vespignani, A
影响因子：
2.6
作者：
Charlton, R. A.;Barrick, T. R.;Morris, R. G.
通讯作者：
Morris, R. G.
影响因子：
34.7
作者：
Faisal, A. Aldo;Selen, Luc P. J.;Wolpert, Daniel M.
通讯作者：
Wolpert, Daniel M.