Longitudinal risk factors for developing depressive symptoms in Parkinson's disease.
Longitudinal risk factors for developing depressive symptoms in Parkinson's disease.
复制标题
DOI：
10.1016/j.jns.2021.117615
复制
发表时间：
2021-10-15
影响因子：
4.4
通讯作者：
Iwaki H
中科院分区：
文献类型：
--
作者：
Antar T;Morris HR;Faghri F;Leonard HL;Nalls MA;Singleton AB;Iwaki H
尽管确定帕金森氏症中抑郁症的重要性，但我们对导致帕金森氏症患者未来抑郁风险的因素的了解有限。我们的样本包括来自两个纵向队列的874名患者，PPMI和PDBP，中位随访时间分别为7年和3年。用Logistic回归分析基线时抑郁症状的危险因素。然后使用COX回归模型来确定基线因素，这些因素使非抑郁症患者容易出现持续至少一年的抑郁症状，同时调整了抗抑郁药物的使用和认知障碍。用随机效应荟萃分析确定了两个队列之间的共同预测因素。我们在分析中发现，大多数基线非抑郁患者在研究过程中至少会出现一次持续的抑郁症状。在两个队列中，可能的快速眼动睡眠行为障碍(PRBD)、年龄、诊断持续时间、日常活动障碍、轻度便秘和抗抑郁药物的使用都是抑郁症的基线危险因素。我们的COX回归模型表明，pRBD、日常活动障碍、营养不良和轻度便秘可以作为持续性抑郁症状的纵向预测因子。我们确定了几个潜在的危险因素，以帮助医生及早发现帕金森病患者的抑郁。我们的发现也强调了在分析抑郁症的风险因素时调整多个协变量的重要性。
Despite the established importance of identifying depression in Parkinson’s disease, our understanding of the factors which place the Parkinson’s disease patient at future risk of depression is limited. Our sample consisted of 874 patients from two longitudinal cohorts, PPMI and PDBP, with median follow-up durations of 7 and 3 years respectively. Risk factors for depressive symptoms at baseline were determined using logistic regression. A Cox regression model was then used to identify baseline factors that predisposed the non-depressed patient to develop depressive symptoms that were sustained for at least one year, while adjusting for antidepressant use and cognitive impairment. Common predictors between the two cohorts were identified with a random-effects meta-analysis. We found in our analyses that the majority of baseline non-depressed patients would develop sustained depressive symptoms at least once during the course of the study. Probable REM sleep behavior disorder (pRBD), age, duration of diagnosis, impairment in daily activities, mild constipation, and antidepressant use were among the baseline risk factors for depression in either cohort. Our Cox regression model indicated that pRBD, impairment in daily activities, hyposmia, and mild constipation could serve as longitudinal predictors of sustained depressive symptoms. We identified several potential risk factors to aid physicians in the early detection of depression in Parkinson’s disease patients. Our findings also underline the importance of adjusting for multiple covariates when analyzing risk factors for depression.
登录
查看更多内容
影响因子：
4.8
作者：
Boeve, Bradley F.;Molano, Jennifer R.;Ferman, Tanis J.;Smith, Glenn E.;Lin, Siong-Chi;Bieniek, Kevin;Haidar, Wael;Tippmann-Peikert, Maja;Knopman, David S.;Graff-Radford, Neill R.;Lucas, John A.;Petersen, Ronald C.;Silber, Michael H.
通讯作者：
Silber, Michael H.
影响因子：
5.6
作者：
Marsh L
通讯作者：
Marsh L
影响因子：
3.1
作者：
Kay DB;Tanner JJ;Bowers D
通讯作者：
Bowers D
影响因子：
2.9
作者：
DOTY, RL;SHAMAN, P;DANN, M
通讯作者：
DANN, M
Ninds帕金森氏病生物标志物计划。
DOI：
10.1002/mds.26438
发表时间：
2016-06
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Rosenthal LS;Drake D;Alcalay RN;Babcock D;Bowman FD;Chen-Plotkin A;Dawson TM;Dewey RB Jr;German DC;Huang X;Landin B;McAuliffe M;Petyuk VA;Scherzer CR;Hillaire-Clarke CS;Sieber BA;Sutherland M;Tarn C;West A;Vaillancourt D;Zhang J;Gwinn K;PDBP consortium
通讯作者：
PDBP consortium