Allergy is associated with suicide completion with a possible mediating role of mood disorder - a population-based study.
Allergy is associated with suicide completion with a possible mediating role of mood disorder - a population-based study.
复制标题
DOI：
10.1111/j.1398-9995.2010.02523.x
复制
发表时间：
2011-05
期刊：
影响因子：
12.4
通讯作者：
Postolache TT
中科院分区：
文献类型：
--
作者：
Qin P;Mortensen PB;Waltoft BL;Postolache TT
随着越来越多的研究表明过敏对自杀的作用，这项研究在人群水平上深入研究了过敏如何影响情绪障碍和其他因素背景下自杀完成的风险。基于丹麦的整个人口，我们纳入了27,096例自杀完成者和467,571例在性别和年龄上匹配的活对照，采用巢式病例对照设计。我们从丹麦纵向登记处检索了医院过敏接触者的个人信息和其他变量，并采用条件logistic回归分析了数据。我们注意到，1.17%的自杀受害者，与0.79%的匹配对照组相比，有医院过敏接触史，过敏史预示自杀完成的风险增加;然而，影响仅限于导致住院治疗的过敏（IRR：1.59，95%CI：1.41-1.80）。增加的风险有所减弱，但在调整个人精神病史和社会经济地位后仍然显着。与此同时，我们观察到女性的影响不显著强于男性，并且年龄差异显著，对高年龄个体的影响更强。此外，我们发现过敏和情绪障碍之间存在显著的相互作用，甚至是两种暴露的拮抗作用。过敏只会增加没有情绪障碍史的人的自杀风险，而它会消除那些有情绪障碍史的人的自杀风险。研究结果支持过敏和自杀之间的联系，情绪障碍可能起着中介作用。
With increasing research suggesting a role of allergy on suicidality, this study, on a population level, delved into how allergy affects risk for suicide completion in the context of mood disorder and other factors. Based on the entire population of Denmark, we included 27,096 completed suicides and 467,571 live controls matched on sex and age with a nested case-control design. We retrieved personal information on hospital contacts for allergy and other variables from various Danish longitudinal registries, and analyzed the data with conditional logistic regression. We noted that 1.17% suicide victims, compared with 0.79% matched controls, had a history of hospital contact for allergy, and that a history of allergy predicted an increased risk for suicide completion; however, the effect was confined to allergy that led to inpatient treatment (IRR: 1.59, 95% CI: 1.41–1.80). The increased risk was attenuated somewhat but remained significant when adjusted for personal psychiatric history and socioeconomic status. Meanwhile, we observed a non-significantly stronger effect in women than in men, and a significant age-difference with a stronger effect for individuals at high ages. Moreover, we detected a significant interaction between allergy and mood disorder – even an antagonism effect of the two exposures. Allergy increased suicide risk only in persons with no history of mood disorder whereas it eliminated suicide risk in those with a history of mood disorder. The findings support a link between allergy and suicidality, with a possible mediating role of mood disorder.
登录
查看更多内容
影响因子：
6.7
作者：
MAES, M;MELTZER, HY;DEMEYER, F
通讯作者：
DEMEYER, F
影响因子：
11
作者：
Timonen, M;Jokelainen, J;Räsänen, P
通讯作者：
Räsänen, P
影响因子：
--
作者：
Sacre, Sandra;Medghalchi, Mino;Williams, Richard
通讯作者：
Williams, Richard
影响因子：
5
作者：
Hurwitz, EL;Morgenstern, H
通讯作者：
Morgenstern, H
影响因子：
64.8
作者：
Galli, Stephen J.;Tsai, Mindy;Piliponsky, Adrian M.
通讯作者：
Piliponsky, Adrian M.