Vascular biomarkers from optical coherence tomography angiography and glaucoma: where do we stand in 2021?
Vascular biomarkers from optical coherence tomography angiography and glaucoma: where do we stand in 2021?
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DOI：
10.1111/aos.14982
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发表时间：
2022-03
影响因子：
3.4
通讯作者：
Oddone F
中科院分区：
文献类型：
--
作者：
Shin JD;Wolf AT;Harris A;Verticchio Vercellin A;Siesky B;Rowe LW;Packles M;Oddone F
几十年来，源于各种成像方式的眼血流生物标志物与青光眼发作和进展相关。包括光学相干断层扫描血管造影术（OCTA）在内的成像平台的进步已经提供了量化青光眼患者血管变化的能力，以及传统的测量方法，如视网膜神经纤维层厚度（RNFL）和视神经乳头（ONH）结构。通过OCTA测量的血管生物标志物的当前文献表明青光眼与视网膜和ONH中的血流和毛细血管密度之间存在显著关系。然而，目前可用的数据是高度多样化的，缺乏关于OCTA血管结局和青光眼进展的可靠纵向数据。在此，我们讨论并总结了2020年12月14日至2021年3月1日期间审查的关于OCTA血管生物标志物和青光眼的相关现有文献。OCTA血管生物标志物与临床结构和功能性青光眼结果之间的关联以及青光眼患者和健康对照之间的差异进行了综述和总结。现有的数据表明，与对照组相比，青光眼患者的ONH、视乳头周围血管层和黄斑中的血流密度、血流指数和血管密度显著降低。与对照组相比，青光眼患者的全像血管密度也显著降低，并且已发现该结果对应于视野丧失的严重程度。OCTA血管生物标志物与临床结构结局一起可能有助于评估患者青光眼的总体风险。
Biomarkers of ocular blood flow originating from a wide variety of imaging modalities have been associated with glaucoma onset and progression for many decades. Advancements in imaging platforms including optical coherence tomography angiography (OCTA) have provided the ability to quantify vascular changes in glaucoma patients, alongside traditional measures such as retinal nerve fiber layer thickness (RNFL) and optic nerve head (ONH) structure. Current literature on vascular biomarkers, as measured by OCTA, indicates significant relationships between glaucoma and blood flow and capillary density in the retina and ONH. The data currently available, however, is highly diverse and lacks robust longitudinal data on OCTA vascular outcomes and glaucoma progression. Herein we discuss and summarize the relevant current literature on OCTA vascular biomarkers and glaucoma reviewed from December 14, 2020 through March 1, 2021. Associations between OCTA vascular biomarkers and clinical structural and functional glaucoma outcomes as well as differences between glaucoma patients and healthy controls are reviewed and summarized. The available data identifies significantly decreased flow density, flow index, and vessel density in the ONH, peripapillary vascular layer, and macula of glaucoma patients compared to controls. Whole image vessel density is also significantly decreased in glaucoma patients compared to controls and this outcome has been found to correspond to severity of visual field loss. OCTA vascular biomarkers alongside clinical structural outcomes may aid in assessing overall risk for glaucoma in patients.
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原发性开角型青光眼进行性黄斑血管密度损失：一项纵向研究。
影响因子：
4.2
作者：
Shoji T;Zangwill LM;Akagi T;Saunders LJ;Yarmohammadi A;Manalastas PIC;Penteado RC;Weinreb RN
通讯作者：
Weinreb RN
影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
影响因子：
3.7
作者：
Munk MR;Giannakaki-Zimmermann H;Berger L;Huf W;Ebneter A;Wolf S;Zinkernagel MS
通讯作者：
Zinkernagel MS
DOI：
10.1007/s00417-018-3965-1
发表时间：
2018-08-01
影响因子：
2.7
作者：
Lommatzsch, C.;Rothaus, K.;Grisanti, S.
通讯作者：
Grisanti, S.
影响因子：
2.2
作者：
Lu, Yifan;Wang, Jay;Miller, John B.
通讯作者：
Miller, John B.