Solvent/non-solvent sintering: a novel route to create porous microsphere scaffolds for tissue regeneration.
Solvent/non-solvent sintering: a novel route to create porous microsphere scaffolds for tissue regeneration.
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DOI：
10.1002/jbm.b.31033
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发表时间：
2008-08
影响因子：
3.4
通讯作者：
Laurencin, Cato T.
中科院分区：
文献类型：
--
作者：
Brown, Justin L.;Nair, Lakshmi S.;Laurencin, Cato T.
溶剂/非溶剂烧结产生适用于组织工程目的的多孔聚合物微球支架，并控制所得孔隙率、平均孔径和机械性能。研究了五种不同的生物可降解生物相容性聚磷腈，其玻璃化转变温度从−8°C到41 ° C，以及聚（丙交酯-共-乙交酯）（PLAGA），一种用于许多生物医学环境的可降解聚合物，以研究该工艺的多功能性并将该工艺基准用于热烧结。参数如：溶剂/非溶剂烧结溶液组成和浸没时间影响烧结过程。用溶剂/非溶剂烧结制造的PLAGA微球支架分别表现出31.9%和179.1μm的互连孔隙率和孔径，这与常规热烧结的PLAGA微球支架类似。生物可降解聚磷腈微球支架的最大连通孔隙率为37.6%，最大压缩模量为94.3MPa。溶剂/非溶剂烧结是在环境条件下烧结具有广谱玻璃化转变温度的聚合物微球的有效策略，使其成为开发组织工程支架和药物递送载体的优异制造路线。
Solvent/non-solvent sintering creates porous polymeric microsphere scaffolds suitable for tissue engineering purposes with control over the resulting porosity, average pore diameter and mechanical properties. Five different biodegradable biocompatible polyphosphazenes exhibiting glass transition temperatures from −8°C to 41oC and poly(lactide-co-glycolide), (PLAGA) a degradable polymer used in a number of biomedical settings, were examined to study the versatility of the process and benchmark the process to heat sintering. Parameters such as: solvent/non-solvent sintering solution composition and submersion time effect the sintering process. PLAGA microsphere scaffolds fabricated with solvent/non-solvent sintering exhibited an interconnected porosity and pore size of 31.9% and 179.1µm respectively which was analogous to that of conventional heat sintered PLAGA microsphere scaffolds. Biodegradable polyphosphazene microsphere scaffolds exhibited a maximum interconnected porosity of 37.6% and a maximum compressive modulus of 94.3MPa. Solvent/non-solvent sintering is an effective strategy for sintering polymeric microspheres, with a broad spectrum of glass transition temperatures, under ambient conditions making it an excellent fabrication route for developing tissue engineering scaffolds and drug delivery vehicles.
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影响因子：
5.5
作者：
ALLCOCK, HR;PUCHER, SR;SCOPELIANOS, AG
通讯作者：
SCOPELIANOS, AG
影响因子：
5.5
作者：
VRENTAS, JS;VRENTAS, CM
通讯作者：
VRENTAS, CM
影响因子：
14
作者：
Borden, M;Attawia, M;Laurencin, CT
通讯作者：
Laurencin, CT
DOI：
10.1002/jbm.10201
发表时间：
2002-09-05
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
Borden, M;Attawia, M;Laurencin, CT
通讯作者：
Laurencin, CT
影响因子：
14
作者：
Akay, G;Birch, MA;Bokhari, MA
通讯作者：
Bokhari, MA