How air pollution alters brain development: the role of neuroinflammation.
How air pollution alters brain development: the role of neuroinflammation.
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DOI：
10.1515/tnsci-2016-0005
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发表时间：
2016
影响因子：
2.1
通讯作者：
D'Angiulli A
中科院分区：
文献类型：
--
作者：
Brockmeyer S;D'Angiulli A
本综述综合了一系列新出现的证据，表明生活在世界各地大城市的几个儿童样本在一定程度上受到与空气污染暴露相关的神经，行为和认知变化的影响。阻止有毒颗粒进入的天然屏障，包括鼻、肠和肺上皮屏障的破坏，以及血脑屏障的普遍破坏，便利了空气传播的污染物进入年轻城市居民的身体。广泛的神经炎症导致中枢神经系统内的细胞损失，并且可能是认知缺陷可能出现的关键机制。虽然微妙，但空气污染对神经认知的影响是巨大的，在所有人群中都很明显，并且可能与临床相关，作为神经退行性变化的早期证据。神经炎症风险的扩散性质表明，综合神经科学方法结合了当前的临床，认知，神经生理学，放射学和流行病学研究。神经儿科空气污染研究需要广泛的多学科合作，以实现通过具有广泛影响和范围的多维干预措施保护暴露儿童的目标。虽然在全球范围内通过改善环境质量进行干预势在必行，但我们还需要制定有效的策略，以监测对当地儿科人群的神经认知影响。
The present review synthesizes lines of emerging evidence showing how several samples of children populations living in large cities around the world suffer to some degree neural, behavioral and cognitive changes associated with air pollution exposure. The breakdown of natural barriers warding against the entry of toxic particles, including the nasal, gut and lung epithelial barriers, as well as widespread breakdown of the blood-brain barrier facilitatethe passage of airborne pollutants into the body of young urban residents. Extensive neuroinflammation contributes to cell loss within the central nervous system, and likely is a crucial mechanism by which cognitive deficits may arise. Although subtle, neurocognitive effects of air pollution are substantial, apparent across all populations, and potentially clinically relevant as early evidence of evolving neurodegenerative changes. The diffuse nature of the neuroinflammation risk suggests an integrated neuroscientific approach incorporating current clinical, cognitive, neurophysiological, radiological and epidemiologic research. Neuropediatric air pollution research requires extensive multidisciplinary collaborations to accomplish the goal of protecting exposed children through multidimensional interventions having both broad impact and reach. While intervening by improving environmental quality at a global scale is imperative, we also need to devise efficient strategies on how the neurocognitive effects on local pediatric populations should be monitored.
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影响因子：
12.7
作者：
Braak, Heiko;Del Tredici, Kelly
通讯作者：
Del Tredici, Kelly
影响因子：
5.1
作者：
Dobyns, EL;Eells, PL;Abman, SH
通讯作者：
Abman, SH
在四项基于欧洲人群的队列研究中，怀孕和儿童自闭症特征期间的空气污染暴露：逃生项目。
影响因子：
10.4
作者：
Guxens M;Ghassabian A;Gong T;Garcia-Esteban R;Porta D;Giorgis-Allemand L;Almqvist C;Aranbarri A;Beelen R;Badaloni C;Cesaroni G;de Nazelle A;Estarlich M;Forastiere F;Forns J;Gehring U;Ibarluzea J;Jaddoe VW;Korek M;Lichtenstein P;Nieuwenhuijsen MJ;Rebagliato M;Slama R;Tiemeier H;Verhulst FC;Volk HE;Pershagen G;Brunekreef B;Sunyer J
通讯作者：
Sunyer J
影响因子：
2.5
作者：
Calderon-Garciduenas, Lilian;Engle, Randall;D'Angiulli, Amedeo
通讯作者：
D'Angiulli, Amedeo
影响因子：
3.6
作者：
Baccarelli A;Bollati V
通讯作者：
Bollati V