Probing striatal function in obsessive-compulsive disorder: a PET study of implicit sequence learning.
Probing striatal function in obsessive-compulsive disorder: a PET study of implicit sequence learning.
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探索强迫症中的纹状体功能：内隐序列学习的 PET 研究。
DOI：
10.1176/jnp.9.4.568
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Jenike,MA
中科院分区：
文献类型：
--
作者：
Rauch,SL;Savage,CR;Alpert,NM;Dougherty,D;Kendrick,A;Curran,T;Brown,HD;Manzo,P;Fischman,AJ;Jenike,MA
强迫症（OCD）是一种常见的精神疾病，影响着全球1%以上的人口。它的特征是焦虑症。强迫症的标志性症状包括侵入性想法（强迫症）以及仪式性行为（强迫症）。大量证据表明，皮质纹状体功能障碍与强迫症的病理生理有关。神经影像学研究7已证实尾状核体积异常。78影像学研究也揭示了眶额皮质和尾状核的静息高代谢7'9 '0（在成功的药物治疗或行为治疗后减弱' 2），以及当强迫症症状被激发时，这些相同区域的激活增加。3此外，有报告称，患者患有后天性纹状体病变，最初的临床表现是强迫症的表型。4皮质纹状体系统被认为调节各种正常功能，包括一种称为内隐（或更具体地说，程序）学习的无意识学习形式。5内隐学习和记忆是指在不伴随对其内容的意识或对行为的影响的情况下获得和表达信息。外显学习和记忆是指伴随着对所学信息的意识及其对信息的获取和提取的过程。
Q bsessive-compulsive disorder (OCD) is a common psychiatric disease, affecting more than 1% of the population worldwide.’ It is characterized as an anxiety disorder. 2 The hallmark symptoms of OCD include intrusive thoughts(obsessions) as well as ritualistic behaviors(compulsions). Substantial evidence has accrued implicating corticostriatal dysfunction in the pathophysiology of OCD. Neuroimaging studies7 have demonstrated volumetric abnormalities involving the caudate nucleus. 78 Imaging studies have also revealed resting hypermetabolism in the orbitofrontal cortex and caudate nucleus7’9’0(attenuated following successful medication or behavioral therapy’2), as well as increased activation of these same areas when OCD symptoms are provoked.’3 Furthermore, cases have been reported of patients with acquired striatal lesions in which the initial clinical presentations are phenocopies of OCD.’4Corticostriatal systems are thought to mediate a variety of normal functions, including a nonconscious form of learning called implicit (or more specifically, procedural) learning.’5 Implicit learning and memory refer to the acquisition and expression of information not accompanied by awareness of its content or influence on behavior. Explicit learning and memory refer to the acquisition and retrieval of information that is accompanied by awareness of the learned information and its
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DOI：
10.3758/bf03327132
发表时间：
1993
期刊：
Psychobiology
影响因子：
--
作者：
D. Willingham;W. Koroshetz
通讯作者：
W. Koroshetz
影响因子：
29
作者：
J. Weilburg;M. Mesulam;S. Weintraub;F. Buonanno;M. Jenike;J. Stakes
通讯作者：
J. Stakes
DOI：
10.1176/ajp.152.1.76
发表时间：
1995
期刊：
The American journal of psychiatry
影响因子：
--
作者：
D. Pauls;J. Alsobrook;W. Goodman;S. Rasmussen;J. Leckman
通讯作者：
D. Pauls;J. Alsobrook;W. Goodman;S. Rasmussen;J. Leckman
DOI：
10.1073/pnas.93.1.321
发表时间：
1996-01-09
影响因子：
11.1
作者：
Schacter, DL;Alpert, NM;Albert, MS
通讯作者：
Albert, MS
影响因子：
--
作者：
S. Rauch;C. Savage;N. Alpert;E. Miguel;L. Baer;H. Breiter;A. Fischman;P. Manzo;Cara Moretti;M. Jenike
通讯作者：
S. Rauch;C. Savage;N. Alpert;E. Miguel;L. Baer;H. Breiter;A. Fischman;P. Manzo;Cara Moretti;M. Jenike