Cyclebase.org: version 2.0, an updated comprehensive, multi-species repository of cell cycle experiments and derived analysis results.
Cyclebase.org: version 2.0, an updated comprehensive, multi-species repository of cell cycle experiments and derived analysis results.
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DOI：
10.1093/nar/gkp1044
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发表时间：
2010-01
影响因子：
14.9
通讯作者：
Jensen TS
中科院分区：
文献类型：
--
作者：
Gauthier NP;Jensen LJ;Wernersson R;Brunak S;Jensen TS
细胞分裂涉及一系列复杂的事件，由数千个分子精心策划。为了研究这一过程，研究人员采用了同步生长细胞培养过程中细胞周期的mRNA表达谱。这些实验已经在几种生物体中进行，不容易获得、组合和评估。复杂的因素包括实验之间分裂时间的变化和生物体之间每个细胞周期阶段的相对持续时间的差异。为了解决这些问题，我们创建了Cyclebase，一个细胞周期相关实验的在线资源。该数据库提供了一个易于使用的网络界面，方便了全基因组细胞周期数据和分析结果的可视化和下载。来自不同实验的数据归一化到一个共同的时间尺度，并补充了关键的细胞周期信息和导出的分析结果。在Cyclebase 2.0版本中，我们更新了整个数据库，以反映基因组注释的变化，包括周期蛋白依赖性激酶（CDK）底物的信息，全基因组筛选预测的降解信号和功能丧失表型。web界面已经得到了改进，并提供了一个单一的，以基因为中心的图表，总结了可用的细胞周期实验。最后，关键信息和链接到同源和旁系基因现在包括进一步促进跨物种细胞周期调控的比较。Cyclebase 2.0版本可从http://www.cyclebase.org获得。
Cell division involves a complex series of events orchestrated by thousands of molecules. To study this process, researchers have employed mRNA expression profiling of synchronously growing cell cultures progressing through the cell cycle. These experiments, which have been carried out in several organisms, are not easy to access, combine and evaluate. Complicating factors include variation in interdivision time between experiments and differences in relative duration of each cell-cycle phase across organisms. To address these problems, we created Cyclebase, an online resource of cell-cycle-related experiments. This database provides an easy-to-use web interface that facilitates visualization and download of genome-wide cell-cycle data and analysis results. Data from different experiments are normalized to a common timescale and are complimented with key cell-cycle information and derived analysis results. In Cyclebase version 2.0, we have updated the entire database to reflect changes to genome annotations, included information on cyclin-dependent kinase (CDK) substrates, predicted degradation signals and loss-of-function phenotypes from genome-wide screens. The web interface has been improved and provides a single, gene-centric graph summarizing the available cell-cycle experiments. Finally, key information and links to orthologous and paralogous genes are now included to further facilitate comparison of cell-cycle regulation across species. Cyclebase version 2.0 is available at http://www.cyclebase.org.
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影响因子：
14.9
作者：
Gauthier NP;Larsen ME;Wernersson R;de Lichtenberg U;Jensen LJ;Brunak S;Jensen TS
通讯作者：
Jensen TS
影响因子：
30.8
作者：
Rustici, G;Mata, J;Bähler, J
通讯作者：
Bähler, J
影响因子：
16
作者：
Cho, RJ;Campbell, MJ;Davis, RW
通讯作者：
Davis, RW
影响因子：
10.5
作者：
Pramila, Tata;Wu, Wei;Breeden, Linda L.
通讯作者：
Breeden, Linda L.
影响因子：
5.1
作者：
Menges, M;Hennig, L;Murray, JAH
通讯作者：
Murray, JAH