Differentiating neural reward responsiveness in autism versus ADHD.
Differentiating neural reward responsiveness in autism versus ADHD.
复制标题
DOI：
10.1016/j.dcn.2014.08.003
复制
发表时间：
2014-10
影响因子：
4.7
通讯作者：
Konrad K
中科院分区：
文献类型：
--
作者：
Kohls G;Thönessen H;Bartley GK;Grossheinrich N;Fink GR;Herpertz-Dahlmann B;Konrad K
研究了ADHD与ASD对社会和金钱奖励的大脑反应。临床组与TDC组对两种奖励的腹侧纹状体激活不同。内侧前额叶过度激活对社会奖励的反应是ADHD特有的。对金钱奖励反应的腹侧纹状体激活不足是ASD特有的。两个临床组都存在为钱而产生的额-纹状体-顶叶激活不足。尽管注意缺陷多动障碍（ADHD）和自闭症谱系障碍（ASD）具有某些共同的神经认知特征，但人们假设可以根据大脑对社会或金钱奖励的奖励反应来区分这两种疾病。因此，本fMRI研究调查了与典型对照相比，年龄和智商匹配的ADHD和ASD男孩对两种奖励类型的神经激活反应（TDC）。在腹侧纹状体中出现了显著的奖励类型相互作用组，仅在TDC中对货币奖励的激活比社会奖励更大，而ADHD受试者对两种奖励类型的反应同样强烈，而ASD受试者在两种奖励条件下均表现出较低的纹状体反应。此外，研究还发现了特定障碍的神经异常，包括ADHD患者对社会奖励的内侧前额叶过度激活，而ASD患者对金钱奖励的腹侧纹状体低激活。当金钱受到威胁时，两个临床组的共同功能障碍的特征是额-纹状体-顶叶活性降低。有趣的是，在整个研究样本中，顶叶回路中较低的神经激活与较高的自闭症特征有关。总之，目前的研究结果与ASD和ADHD在对奖励的反应中表现出不同和共同的神经功能障碍的假设一致。
Brain responsiveness to social and monetary reward were studied in ADHD versus ASD. Clinical groups versus TDC had different ventral striatum activation to both rewards. Medial prefrontal overactivation in response to social reward was ADHD specific. Ventral striatal underactivation in response to monetary reward was ASD specific. Fronto-striato-parietal underactivation for money was shared by both clinical groups. Although attention deficit hyperactivity disorders (ADHD) and autism spectrum disorders (ASD) share certain neurocognitive characteristics, it has been hypothesized to differentiate the two disorders based on their brain's reward responsiveness to either social or monetary reward. Thus, the present fMRI study investigated neural activation in response to both reward types in age and IQ-matched boys with ADHD versus ASD relative to typically controls (TDC). A significant group by reward type interaction effect emerged in the ventral striatum with greater activation to monetary versus social reward only in TDC, whereas subjects with ADHD responded equally strong to both reward types, and subjects with ASD showed low striatal reactivity across both reward conditions. Moreover, disorder-specific neural abnormalities were revealed, including medial prefrontal hyperactivation in response to social reward in ADHD versus ventral striatal hypoactivation in response to monetary reward in ASD. Shared dysfunction was characterized by fronto-striato-parietal hypoactivation in both clinical groups when money was at stake. Interestingly, lower neural activation within parietal circuitry was associated with higher autistic traits across the entire study sample. In sum, the present findings concur with the assumption that both ASD and ADHD display distinct and shared neural dysfunction in response to reward.
登录
查看更多内容
影响因子：
4.9
作者：
Dichter GS;Damiano CA;Allen JA
通讯作者：
Allen JA
影响因子：
6.9
作者：
Becker, Stephen P.;Luebbe, Aaron M.;Langberg, Joshua M.
通讯作者：
Langberg, Joshua M.
影响因子：
2.9
作者：
Dadds, Mark R.;Hunter, Kirsten;El Masry, Yasmeen
通讯作者：
El Masry, Yasmeen
影响因子：
4.9
作者：
Cascio CJ;Foss-Feig JH;Heacock JL;Newsom CR;Cowan RL;Benningfield MM;Rogers BP;Cao A
通讯作者：
Cao A
DOI：
10.1111/j.1469-7610.2009.02201.x
发表时间：
2010-07
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Bjork JM;Chen G;Smith AR;Hommer DW
通讯作者：
Hommer DW