Prefrontal neurons predict choices during an auditory same-different task.
Prefrontal neurons predict choices during an auditory same-different task.
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DOI:
10.1016/j.cub.2008.08.054
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发表时间:
2008-10-14
期刊:
影响因子:
9.2
通讯作者:
Cohen, Yale E.
中科院分区:
文献类型:
--
作者:
Russ, Brian E.;Orr, Lauren E.;Cohen, Yale E.
The detection of stimuli is critical for an animal’s survival. However, it is not adaptive for an animal to respond automatically to every stimulus that is present in the environment. Since the prefrontal cortex (PFC) plays a key role in executive function, we hypothesized that PFC activity should be involved in context-dependent responses to uncommon stimuli. To test this hypothesis, monkeys participated in a same-different task, a variant of an oddball task. During this task, a monkey heard multiple presentations of a “reference” stimulus that was followed by a “test” stimulus and reported whether these stimuli were the same or different. While they participated in this task, we recorded from neurons in the ventrolateral prefrontal cortex (vPFC; a cortical area involved in aspects of non-spatial auditory processing). We found that vPFC activity was correlated with the monkeys’ choices. This finding demonstrates a direct link between single neurons and behavioral choices in the PFC on a non-spatial auditory task.
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