Prefrontal neurons predict choices during an auditory same-different task.

Prefrontal neurons predict choices during an auditory same-different task.
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DOI:
10.1016/j.cub.2008.08.054
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发表时间:
2008-10-14
期刊:
影响因子:
9.2
通讯作者:
Cohen, Yale E.
Cohen, Yale E.
中科院分区:
生物学1区
文献类型:
--
作者:
Russ, Brian E.;Orr, Lauren E.;Cohen, Yale E.

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刺激的检测对于动物的生存至关重要。然而,动物并不能自动对环境中存在的每种刺激做出反应。由于前额皮质(PFC)在执行功能中发挥着关键作用,我们假设 PFC 活动应该参与对不常见刺激的上下文依赖性反应。为了检验这个假设,猴子参与了一项相同但不同的任务,这是奇怪任务的一种变体。在这项任务中,一只猴子听到了“参考”刺激的多次呈现,然后是“测试”刺激,并报告这些刺激是否相同或不同。当他们参与这项任务时,我们记录了腹外侧前额皮质(vPFC;涉及非空间听觉处理方面的皮质区域)的神经元。我们发现 vPFC 活性与猴子的选择相关。这一发现证明了非空间听觉任务中单个神经元与 PFC 中的行为选择之间存在直接联系。
The detection of stimuli is critical for an animal’s survival. However, it is not adaptive for an animal to respond automatically to every stimulus that is present in the environment. Since the prefrontal cortex (PFC) plays a key role in executive function, we hypothesized that PFC activity should be involved in context-dependent responses to uncommon stimuli. To test this hypothesis, monkeys participated in a same-different task, a variant of an oddball task. During this task, a monkey heard multiple presentations of a “reference” stimulus that was followed by a “test” stimulus and reported whether these stimuli were the same or different. While they participated in this task, we recorded from neurons in the ventrolateral prefrontal cortex (vPFC; a cortical area involved in aspects of non-spatial auditory processing). We found that vPFC activity was correlated with the monkeys’ choices. This finding demonstrates a direct link between single neurons and behavioral choices in the PFC on a non-spatial auditory task.
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