Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission.

Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission.
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DOI:
10.1038/nrm3395
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发表时间:
2012-07-11
期刊:
Nature reviews. Molecular cell biology
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在细胞分裂的最后阶段,未来的子细胞在称为脱落的过程中物理分离。这个过程需要协调许多分子机器,这些分子机器介导一系列复杂的事件,最终导致子细胞的最终分离。脱落通过有丝分裂激酶与其他细胞过程(例如核孔重组)协调,有丝分裂激酶充当主调节器以确保脱落的正确进展。
During the final stage of cell division, the future daughter cells are physically separated in a process called abscission. This process requires coordination of a number of molecular machines that mediate a complex series of events to culminate in the final separation of daughter cells. Abscission is coordinated with other cellular processes (for example, nuclear pore reassembly) through mitotic kinases that act as master regulators to ensure proper progression of abscission.
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