Learning in the Rodent Motor Cortex.
Learning in the Rodent Motor Cortex.
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DOI：
10.1146/annurev-neuro-072116-031407
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发表时间：
2017-07-25
影响因子：
13.9
通讯作者：
Komiyama T
中科院分区：
文献类型：
--
作者：
Peters AJ;Liu H;Komiyama T
运动皮层远不是一个稳定的运动指令管道，而是在学习过程中经历重大变化。以啮齿类动物为实验动物，对运动皮层可塑性的认识有了很大的进展。这项研究的两个主要焦点是运动皮层的连接和活动。运动皮层表现出响应于学习的结构变化，并且大量证据表明新突触的局部形成和维持是运动学习的关键底物。这种突触重组转化为尖峰活动的变化，这似乎导致运动皮层活动和运动之间的关系的修改和细化。本文综述了利用啮齿类动物建立运动皮层作为支持运动学习的适应性结构所取得的进展。
The motor cortex is far from a stable conduit for motor commands and instead undergoes significant changes during learning. An understanding of motor cortex plasticity has been advanced greatly using rodents as experimental animals. Two major focuses of this research have been on the connectivity and activity of the motor cortex. The motor cortex exhibits structural changes in response to learning, and substantial evidence has implicated the local formation and maintenance of new synapses as crucial substrates of motor learning. This synaptic reorganization translates into changes in spiking activity, which appear to result in a modification and refinement of the relationship between motor cortical activity and movement. This review presents the progress that has been made using rodents to establish the motor cortex as an adaptive structure that supports motor learning.
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影响因子：
25
作者：
Anderson, Charles T.;Sheets, Patrick L.;Kiritani, Taro;Shepherd, Gordon M. G.
通讯作者：
Shepherd, Gordon M. G.
影响因子：
16.2
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5.3
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16.2
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影响因子：
2.5
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通讯作者：
SAKATA, H