Chronic viral infection and primary central nervous system malignancy.
Chronic viral infection and primary central nervous system malignancy.
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DOI：
10.1007/s11481-010-9204-0
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发表时间：
2010-09
影响因子：
6.2
通讯作者：
Crawford, John R.
中科院分区：
文献类型：
--
作者：
Saddawi-Konefka, Robert;Crawford, John R.
原发性中枢神经系统（CNS）肿瘤在成人和儿童中都会导致显着的发病率和死亡率。虽然神经肿瘤发生的一些遗传和分子机制是已知的，但对疾病病理生理学的可能表观遗传贡献知之甚少。在过去的几十年里，慢性病毒感染与许多人类恶性肿瘤有关。在原发性中枢神经系统恶性肿瘤中，两个病毒家族，即多瘤病毒和疱疹病毒，在许多儿科和成人组织学肿瘤亚型中以不同的频率检测到。然而，建立慢性病毒感染和原发性CNS恶性肿瘤之间的联系一直是一个相当有争议的领域，部分原因是研究人员之间使用的检测频率和方法的变化。由于潜伏的病毒嗜神经性可以与各种病毒和广泛的血清阳性人群中存在，它一直难以建立一个基于流行病学单独的病毒感染和CNS恶性肿瘤之间的关联。虽然缺乏病毒在人类神经肿瘤发生中的作用的直接证据，但已经提出了一种更合理的神经肿瘤调节假说。本综述的总体目标是总结许多研究病毒感染原发性CNS肿瘤的人类研究，讨论病毒相关CNS疾病的潜在神经肿瘤调节机制，并提出未来的研究方向，以建立一个更坚定的慢性病毒感染和原发性CNS恶性肿瘤之间的关联。
Primary central nervous system (CNS) tumors cause significant morbidity and mortality in both adults and children. While some of the genetic and molecular mechanisms of neuro-oncogenesis are known, much less is known about possible epigenetic contributions to disease pathophysiology. Over the last several decades, chronic viral infections have been associated with a number of human malignancies. In primary CNS malignancies, two families of viruses, namely polyomavirus and herpesvirus, have been detected with varied frequencies in a number of pediatric and adult histological tumor subtypes. However, establishing a link between chronic viral infection and primary CNS malignancy has been an area of considerable controversy, due in part to variations in detection frequencies and methodologies used among researchers. Since a latent viral neurotropism can be seen with a variety of viruses and a widespread seropositivity exists among the population, it has been difficult to establish an association between viral infection and CNS malignancy based on epidemiology alone. While direct evidence of a role of viruses in neuro-oncogenesis in humans is lacking, a more plausible hypothesis of neuro-oncomodulation has been proposed. The overall goals of this review are to summarize the many human investigations that have studied viral infection in primary CNS tumors, discuss potential neuro-oncomodulatory mechanisms of viral-associated CNS disease and propose future research directions to establish a more firm association between chronic viral infections and primary CNS malignancies.
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