Exercise improves health-related quality of life sleep and fatigue domains in adult high- and low-grade glioma patients.
Exercise improves health-related quality of life sleep and fatigue domains in adult high- and low-grade glioma patients.
复制标题
DOI：
10.1007/s00520-021-06566-2
复制
发表时间：
2022-02
影响因子：
3.1
通讯作者：
Smith, Sean
中科院分区：
文献类型：
--
作者：
Miklja, Zachary;Gabel, Nicolette;Altshuler, David;Wang, Lin;Hervey-Jumper, Shawn L.;Smith, Sean
关键词：
运动对胶质瘤患者健康相关生活质量（HRQOL）的影响尚不清楚。我们假设运动耐量低的胶质瘤患者在HRQOL睡眠和疲劳领域比运动耐量高的患者经历更多的痛苦。38名男性和女性低级别或高级别胶质瘤患者在一个三级医疗机构接受治疗。患者完成了一项有效的电话调查，以确定他们的运动习惯之前和之后的诊断。进行非配对t检验，以测量运动耐量对HRQOL功能和损伤领域之间的相互作用。那些患病前体力活动水平低的人在HRQOL睡眠和疲劳领域有更多的痛苦。这些影响与血浆脑源性神经营养因子（BDNF）水平无关，运动程度似乎不会影响成人胶质瘤患者的血浆BDNF。本研究的目的是探讨运动习惯对低级别或高级别胶质瘤患者围手术期功能结局的意义。我们发现运动耐受性低的胶质瘤患者比运动耐受性高的胶质瘤患者有更多的睡眠障碍和更大的疲劳。此外，运动耐量在成人神经胶质瘤人口似乎没有影响血浆BDNF分泌。
The impact of exercise on health-related quality of life (HRQOL) in patients with glioma remains unknown. We hypothesized that glioma patients with low exercise tolerance experience more distress in HRQOL sleep and fatigue domains than patients with high tolerance to exercise. Thirty-eight male and female patients with low- or high-grade glioma treated at a single tertiary care institution participated. Patients completed a validated telephone survey to determine their exercise habits before and following diagnosis. An unpaired t-test was run to measure the interaction between exercise tolerances on HRQOL functional and impairment domains. Those with low pre-morbid physical activity levels had more distress in HRQOL sleep and fatigue domains. The effects were independent of plasma brain-derived neurotrophic factor (BDNF) levels and the degree of exercise did not appear to impact plasma BDNF in adult glioma patients. The aim of this study was to examine the significance of exercise habits on perioperative functional outcomes in patients with low-grade or high-grade glioma. We found that glioma patients with low tolerance to exercise had more sleep disturbances and greater fatigue than glioma patients with high tolerance to exercise. Furthermore, exercise tolerance in the adult glioma population does not appear to impact plasma BDNF secretion.
登录
查看更多内容
影响因子：
6.2
作者：
Jones, LW;Guill, B;Reardon, DA
通讯作者：
Reardon, DA
影响因子：
3.4
作者：
Gabel, Nicolette;Altshuler, David B.;Hervey-Jumper, Shawn L.
通讯作者：
Hervey-Jumper, Shawn L.
影响因子：
2
作者：
Romero, Melissa M.;Flood, Lisa Sue;Conklin, Samantha
通讯作者：
Conklin, Samantha
影响因子：
4.6
作者：
Barbosa AG;Pratesi R;Paz GSC;Dos Santos MAAL;Uenishi RH;Nakano EY;Gandolfi L;Pratesi CB
通讯作者：
Pratesi CB
DOI：
10.1007/s00520-021-06377-5
发表时间：
2022-01
期刊：
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
影响因子：
--
作者：
Castelli L;Elter T;Wolf F;Watson M;Schenk A;Steindorf K;Bloch W;Hallek M;Joisten N;Zimmer P
通讯作者：
Zimmer P