A portable neurostimulator circuit with anodic bias enhances stimulation injection capacity.
A portable neurostimulator circuit with anodic bias enhances stimulation injection capacity.
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DOI：
10.1088/1741-2552/ac8fb6
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发表时间：
2022-10-05
影响因子：
4
通讯作者：
Han, Martin
中科院分区：
文献类型：
--
作者：
Ersoz, Alpaslan;Kim, Insoo;Han, Martin
目标。电化学上安全有效的神经刺激电荷注入需要监测刺激电极的极化和增强电荷注入能力。在这项工作中，我们通过开发一种定制设计的多通道便携式神经刺激器来提高微刺激能力，该神经刺激器具有完全可编程的阳极偏置电路和电压瞬态监测功能。的方法。我们开发了一个16通道多通道神经刺激器系统，比较了电荷注入能力作为阳极偏压电位的函数，并通过定制设计的用户界面演示了系统的方便控制，允许双向无线传输刺激参数和记录电压瞬变。用硅基氧化铱微电极在磷酸盐缓冲盐水中进行电荷注射。主要的结果。在电荷平衡的200µs阴极第一脉冲下，电荷注入能力与施加的阳极偏置水平成比例地增加，在600 mV阳极偏置下，电流强度从10µa（100µC cm - 2）增加到100µa(1000µC cm - 2)，最大增加了10倍。我们的定制设计和完全便携式16通道神经刺激器使体外电荷注射能力显著增加。的意义。有限的电荷注入能力一直是神经刺激应用的瓶颈，我们的系统可以在确保电化学安全的同时，有效地进行涉及慢性微刺激的动物行为研究。
Objective. Electrochemically safe and efficient charge injection for neural stimulation necessitates monitoring of polarization and enhanced charge injection capacity of the stimulating electrodes. In this work, we present improved microstimulation capability by developing a custom-designed multichannel portable neurostimulator with a fully programmable anodic bias circuitry and voltage transient monitoring feature. Approach. We developed a 16-channel multichannel neurostimulator system, compared charge injection capacities as a function of anodic bias potentials, and demonstrated convenient control of the system by a custom-designed user interface allowing bidirectional wireless data transmission of stimulation parameters and recorded voltage transients. Charge injections were conducted in phosphate-buffered saline with silicon-based iridium oxide microelectrodes. Main results. Under charge-balanced 200 µs cathodic first pulsing, the charge injection capacities increased proportionally to the level of anodic bias applied, reaching a maximum of ten-fold increase in current intensity from 10 µA (100 µC cm−2) to 100 µA (1000 µC cm−2) with a 600 mV anodic bias. Our custom-designed and completely portable 16-channel neurostimulator enabled a significant increase in charge injection capacity in vitro. Significance. Limited charge injection capacity has been a bottleneck in neural stimulation applications, and our system may enable efficacious behavioral animal study involving chronic microstimulation while ensuring electrochemical safety.
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DOI：
10.1109/ner49283.2021.9441282
发表时间：
2021-05
期刊：
International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering
影响因子：
--
作者：
Ersöz A;Kim I;Han M
通讯作者：
Han M
影响因子：
4
作者：
Frederick, Rebecca A.;Troyk, Philip R.;Cogan, Stuart F.
通讯作者：
Cogan, Stuart F.
影响因子：
4
作者：
McCreery D;Pikov V;Troyk PR
通讯作者：
Troyk PR
影响因子：
4
作者：
Callier, Thierri;Schluter, Erik W.;Bensmaia, Sliman J.
通讯作者：
Bensmaia, Sliman J.
影响因子：
4
作者：
McCreery, Douglas;Han, Martin;Pannu, Satinderpall
通讯作者：
Pannu, Satinderpall