Maternal serum leptin during pregnancy and infant birth weight: the influence of maternal overweight and obesity.
Maternal serum leptin during pregnancy and infant birth weight: the influence of maternal overweight and obesity.
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DOI：
10.1002/oby.20128
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发表时间：
2013-05
期刊：
影响因子：
6.9
通讯作者：
Trudeau, Sheri
中科院分区：
文献类型：
--
作者：
Misra, Vinod K.;Straughen, Jennifer K.;Trudeau, Sheri
很少有研究调查肥胖和非肥胖孕妇的不同代谢模式是否会对胎儿生长产生不同的影响。我们的目的是评估母亲血清瘦素水平的纵向变化对超重/肥胖与正常体重妇女的婴儿出生体重变化的影响。在一个前瞻性队列的286名孕妇，我们测量了孕妇体重和血清瘦素水平在6- 10，10 - 14，16 -20，22-26，32-36周妊娠。采用线性回归模型分析瘦素水平对婴儿出生体重的影响，该模型考虑了时变预测因子与对数转换瘦素浓度的关系。超重/肥胖和正常体重孕妇表现出不同的aBW与母体血清瘦素及其在整个妊娠期间的变化率的关系。对于正常体重的妇女，aBW与瘦素浓度的对数大小无关，也与妊娠前半期或后半期瘦素浓度的变化率无关。相反，对于超重/肥胖的妇女，我们发现，在怀孕的后半段母亲血清瘦素的变化率的增加与aBW的减少显着相关。我们发现，这种影响是不同的母亲体重。超重/肥胖和正常体重妇女之间母体血清瘦素对胎儿生长的影响差异表明这些群体之间的代谢和生理异质性。这种差异可能涉及肥胖的宫内环境对后代健康的长期生理影响。
Few studies have examined whether the distinct metabolic patterns found in obese and non-obese pregnant women may have different effects on the growing fetus. Our objective was to estimate the influence of longitudinal variation in maternal serum leptin levels on variation in infant birth weight in overweight/obese versus normal weight women. In a prospective cohort of 286 gravidas, we measured maternal weight and serum leptin levels at 6–10,10–14,16–20, 22–26, and 32–36 weeks gestation. Effects of leptin levels on infant birth weight adjusted for gestational age at delivery (aBW) were analyzed using a linear regression model that accounted for the relationship of time-varying predictors to the log transformed leptin concentrations. Overweight/obese and normal weight gravidas exhibit different relationships of aBW to maternal serum leptin and its rate of change across pregnancy. For normal weight women, aBW is not associated with either the magnitude of the logarithm of the leptin concentration nor with its rate of change in either the first or second half of pregnancy. Conversely, for overweight/obese women, we find that an increase in the rate of change in maternal serum leptin in the second half of pregnancy is significantly associated with a decrease in aBW. We find that this effect is distinct from that of maternal weight. Differences in the effect of maternal serum leptin on fetal growth between overweight/obese and normal weight women suggest metabolic and physiologic heterogeneity between these groups. Such differences may be involved in the long-term physiologic effects of the obese intrauterine environment on the health of the offspring.
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