International estimates of intended uptake and refusal of COVID-19 vaccines: A rapid systematic review and meta-analysis of large nationally representative samples.
International estimates of intended uptake and refusal of COVID-19 vaccines: A rapid systematic review and meta-analysis of large nationally representative samples.
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DOI：
10.1016/j.vaccine.2021.02.005
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发表时间：
2021-04-08
期刊：
影响因子：
5.5
通讯作者：
Daly M
中科院分区：
文献类型：
--
作者：
Robinson E;Jones A;Lesser I;Daly M
广泛接种COVID-19疫苗对控制COVID-19大流行至关重要。疫苗已经在前所未有的时间内开发出来，量化普通人群对疫苗接种的犹豫程度非常重要。对使用大型全国代表性样本（n ≥ 1000）的研究进行系统性综述和荟萃分析，以检查打算接种、不确定或打算拒绝接种COVID-19疫苗的人群比例。一般逆荟萃分析和荟萃回归被用来汇总估计值和检查时间趋势。检索了2020年1月至11月的PubMed、Scopus和预打印服务器。在PROSPERO上注册（CRD 42020223132）。来自13个国家的28个国家代表性样本（n = 58，656）表明，随着大流行的发展，打算接种疫苗的人的百分比下降，而打算拒绝接种疫苗的人的百分比增加。6月至10月期间进行的调查的汇总数据表明，60%（95% CI：49%至69%）的人打算接种疫苗，20%（95% CI：13%至29%）的人打算拒绝接种疫苗，尽管样本和国家之间的意图差异很大（I2 > 90%）。女性、年轻、收入或教育水平较低以及属于少数民族群体始终与不太可能打算接种疫苗有关。高质量与低质量研究的结果一致。各国在COVID-19疫苗可用时接种疫苗的意愿一直在下降，迫切需要解决疫苗犹豫的社会不平等问题，并促进疫苗可用时的广泛接种。N/A.
Widespread uptake of COVID-19 vaccines will be essential to controlling the COVID-19 pandemic. Vaccines have been developed in unprecedented time and quantifying levels of hesitancy towards vaccination among the general population is of importance. Systematic review and meta-analysis of studies using large nationally representative samples (n ≥ 1000) to examine the percentage of the population intending to vaccinate, unsure, or intending to refuse a COVID-19 vaccine when available. Generic inverse meta-analysis and meta-regression were used to pool estimates and examine time trends. PubMed, Scopus and pre-printer servers were searched from January-November 2020. Registered on PROSPERO (CRD42020223132). Twenty-eight nationally representative samples (n = 58,656) from 13 countries indicate that as the pandemic has progressed, the percentage of people intending to vaccinate decreased and the percentage of people intending to refuse vaccination increased. Pooled data from surveys conducted during June-October suggest that 60% (95% CI: 49% to 69%) intend to vaccinate and 20% (95% CI: 13% to 29%) intend to refuse vaccination, although intentions vary substantially between samples and countries (I2 > 90%). Being female, younger, of lower income or education level and belonging to an ethnic minority group were consistently associated with being less likely to intend to vaccinate. Findings were consistent across higher vs. lower quality studies. Intentions to be vaccinated when a COVID-19 vaccine becomes available have been declining across countries and there is an urgent need to address social inequalities in vaccine hesitancy and promote widespread uptake of vaccines as they become available. N/A.
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