Poor sleep quality and exaggerated salivary cortisol reactivity to the cold pressor task predict greater acute pain severity in a non-clinical sample.
Poor sleep quality and exaggerated salivary cortisol reactivity to the cold pressor task predict greater acute pain severity in a non-clinical sample.
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DOI：
10.1016/j.biopsycho.2012.02.020
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发表时间：
2012-09
影响因子：
2.6
通讯作者：
McGuire, Lynanne
中科院分区：
文献类型：
--
作者：
Goodin, Burel R.;Smith, Michael T.;Quinn, Noel B.;King, Christopher D.;McGuire, Lynanne
睡眠不佳通常与更大的疼痛敏感性和下丘脑-垂体-肾上腺（HPA）轴的失调（例如，更大的基础皮质醇和夸大的应激诱导的皮质醇反应性）。然而，睡眠、疼痛和HPA轴之间的相互作用尚未得到充分评估。在这项研究中，40名健康成年人提供了关于在完成急性有害的身体应激源（即，冷加压作业。CPT后，他们报告了疼痛的严重程度。唾液皮质醇采样前，立即，并在恢复CPT。使用带有偏差校正的自举置信区间，结果显示，睡眠质量差与CPT诱导的疼痛严重程度和皮质醇反应性的报告显著相关（即，从基线增加）。此外，更大的皮质醇反应的CPT被发现显着介导睡眠不良和疼痛严重程度之间的关系。
Poor sleep is often independently associated with greater pain sensitivity and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis (e.g., greater basal cortisol and exaggerated stress-induced cortisol reactivity). However, the interactions among sleep, pain, and the HPA axis have not been adequately evaluated. In this study, 40 healthy adults provided self-report regarding perceived sleep quality over the past month prior to completion of an acute noxious physical stressor (i.e., cold pressor task; CPT). Following the CPT, they reported on the severity of pain experienced. Salivary cortisol was sampled before, immediately following, and during recovery from CPT. Using bootstrapped confidence intervals with a bias correction, results showed that poor sleep quality was significantly associated with greater reports of CPT-induced pain severity and greater cortisol reactivity (i.e., increase from baseline). Furthermore, greater cortisol reactivity to the CPT was found to significantly mediate the relationship between poor sleep and pain severity.
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