Pulvinar projections to the striatum and amygdala in the tree shrew.
Pulvinar projections to the striatum and amygdala in the tree shrew.
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DOI：
10.3389/fnana.2010.00143
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发表时间：
2010
影响因子：
2.9
通讯作者：
Bickford ME
中科院分区：
文献类型：
--
作者：
Day-Brown JD;Wei H;Chomsung RD;Petry HM;Bickford ME
在没有有意识的视觉感知的情况下，视觉引导的运动是可能的，这种现象被称为“盲视”。同样，恐惧的图像可以在没有意识感知的情况下引发情绪反应。这两种能力被认为是由视网膜通过上丘（SC）和枕核的通路介导的。为了定义对未察觉的视觉刺激的行为反应的潜在途径，我们检查了树鼩（Tupaia belangeri）（一种被认为是典型灵长类动物的物种）从枕核到纹状体和杏仁核的投射。树鼩的大脑有一个大的枕核，其中包含两个 SC 受体分区；背侧 (Pd) 和中央 (Pc) 丘脑均接收来自 SC 的地形（“特定”）投影，Pd 接收来自 SC 的附加非地形（“漫射”）投影（Chomsung 等人）。顺行和逆行束追踪显示，Pd 和 Pc 均投射到尾状核和壳核，并且 Pd（而非 Pc）还投射到外侧杏仁核。使用 P 物质 (SP) 和小清蛋白 (PV) 的免疫细胞化学染色来揭示树鼩纹状体的斑块/基质组织，我们发现富含 SP/PV 贫乏的斑块与富含 PV/SP 贫乏的基质互锁。共聚焦显微镜显示示踪剂标记的枕纹状体末端优先支配基质。电子显微镜显示，示踪剂标记的枕纹状体和枕状杏仁核末端的突触后目标是棘，表明枕状核投射到纹状体基质和外侧杏仁核的棘状输出细胞，可能传递：（1）从SC到纹状体的地形视觉信息，以帮助指导精确运动，（2）从SC到杏仁核的非地形视觉信息，提醒动物到潜在危险的视觉图像。
Visually guided movement is possible in the absence of conscious visual perception, a phenomenon referred to as “blindsight.” Similarly, fearful images can elicit emotional responses in the absence of their conscious perception. Both capabilities are thought to be mediated by pathways from the retina through the superior colliculus (SC) and pulvinar nucleus. To define potential pathways that underlie behavioral responses to unperceived visual stimuli, we examined the projections from the pulvinar nucleus to the striatum and amygdala in the tree shrew (Tupaia belangeri), a species considered to be a prototypical primate. The tree shrew brain has a large pulvinar nucleus that contains two SC-recipient subdivisions; the dorsal (Pd) and central (Pc) pulvinar both receive topographic (“specific”) projections from SC, and Pd receives an additional non-topographic (“diffuse”) projection from SC (Chomsung et al.,). Anterograde and retrograde tract tracing revealed that both Pd and Pc project to the caudate and putamen, and Pd, but not Pc, additionally projects to the lateral amygdala. Using immunocytochemical staining for substance P (SP) and parvalbumin (PV) to reveal the patch/matrix organization of tree shrew striatum, we found that SP-rich/PV-poor patches interlock with a PV-rich/SP-poor matrix. Confocal microscopy revealed that tracer-labeled pulvino-striatal terminals preferentially innervate the matrix. Electron microscopy revealed that the postsynaptic targets of tracer-labeled pulvino-striatal and pulvino-amygdala terminals are spines, demonstrating that the pulvinar nucleus projects to the spiny output cells of the striatum matrix and the lateral amygdala, potentially relaying: (1) topographic visual information from SC to striatum to aid in guiding precise movements, and (2) non-topographic visual information from SC to the amygdala alerting the animal to potentially dangerous visual images.
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影响因子：
3.7
作者：
Chomsung, Ranida D.;Wei, Haiyang;Bickford, Martha E.
通讯作者：
Bickford, Martha E.
影响因子：
2.5
作者：
Chomsung, Ranida D.;Petry, Heywood M.;Bickford, Martha E.
通讯作者：
Bickford, Martha E.
影响因子：
25
作者：
Amorapanth, P;LeDoux, JE;Nader, K
通讯作者：
Nader, K
影响因子：
2.5
作者：
BECKSTEAD, RM
通讯作者：
BECKSTEAD, RM
DOI：
10.1523/jneurosci.1497-10.2010
发表时间：
2010-06-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cohen JD;Castro-Alamancos MA
通讯作者：
Castro-Alamancos MA