Controlled Drug Delivery Systems: Current Status and Future Directions.
Controlled Drug Delivery Systems: Current Status and Future Directions.
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DOI：
10.3390/molecules26195905
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发表时间：
2021-09-29
期刊：
影响因子：
--
通讯作者：
Ramakrishna S
中科院分区：
文献类型：
--
作者：
Adepu S;Ramakrishna S
所述药物输送系统使活性药物成分的释放达到所需的治疗反应。传统的给药系统（片剂、胶囊、糖浆、软膏等）存在生物利用度差和血浆药物水平波动的问题，无法实现持续释放。如果没有一个有效的输送机制，整个治疗过程就会变得毫无意义。此外，药物必须以特定的控制速率和尽可能精确地递送到目标部位，以达到最大的疗效和安全性。受控给药系统是为了解决与常规给药有关的问题而开发的。在过去的二十年中，从宏观尺度和纳米尺度到智能靶向给药，受控药物给药系统有了巨大的发展。这篇综述的第一部分提供了对药物传递系统的基本了解，重点是药物的药代动力学。它还讨论了传统的给药系统及其局限性。此外，详细讨论了受控药物输送系统的设计考虑，分类和图纸。此外，纳米药物递送，靶向和智能药物递送使用刺激反应和智能生物材料进行了讨论，最近的主要发现。文章最后提出了药物控制给药面临的挑战和未来的发展方向。
The drug delivery system enables the release of the active pharmaceutical ingredient to achieve a desired therapeutic response. Conventional drug delivery systems (tablets, capsules, syrups, ointments, etc.) suffer from poor bioavailability and fluctuations in plasma drug level and are unable to achieve sustained release. Without an efficient delivery mechanism, the whole therapeutic process can be rendered useless. Moreover, the drug has to be delivered at a specified controlled rate and at the target site as precisely as possible to achieve maximum efficacy and safety. Controlled drug delivery systems are developed to combat the problems associated with conventional drug delivery. There has been a tremendous evolution in controlled drug delivery systems from the past two decades ranging from macro scale and nano scale to intelligent targeted delivery. The initial part of this review provides a basic understanding of drug delivery systems with an emphasis on the pharmacokinetics of the drug. It also discusses the conventional drug delivery systems and their limitations. Further, controlled drug delivery systems are discussed in detail with the design considerations, classifications and drawings. In addition, nano-drug delivery, targeted and smart drug delivery using stimuli-responsive and intelligent biomaterials is discussed with recent key findings. The paper concludes with the challenges faced and future directions in controlled drug delivery.
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影响因子：
5.6
作者：
Adepu S;Luo H;Ramakrishna S
通讯作者：
Ramakrishna S
DOI：
10.1007/s43538-021-00012-x
发表时间：
2021-03-01
影响因子：
0.9
作者：
Adepu, Shivakalyani;Khandelwal, Mudrika
通讯作者：
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影响因子：
3.4
作者：
Adepu, Shivakalyani;Khandelwal, Mudrika
通讯作者：
Khandelwal, Mudrika
影响因子：
6.7
作者：
Adepu, Shivakalyani;Gaydhane, Mrunalini K.;Eichhorn, Stephen J.
通讯作者：
Eichhorn, Stephen J.
影响因子：
5.4
作者：
Antimisiaris SG;Mourtas S;Marazioti A
通讯作者：
Marazioti A