Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers.
Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201 administration in patients with olfactory impairments in comparison to healthy volunteers.
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DOI：
10.1371/journal.pone.0057671
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Miwa T
中科院分区：
文献类型：
--
作者：
Shiga H;Taki J;Washiyama K;Yamamoto J;Kinase S;Okuda K;Kinuya S;Watanabe N;Tonami H;Koshida K;Amano R;Furukawa M;Miwa T
本研究的目的是评估嗅觉障碍患者与健康志愿者相比，鼻给药后铊-201 （201Tl）向嗅球的迁移是否减少。10名健康志愿者和21名患者参加了这项研究（19名男性和12名女性；26-71岁）。患者嗅觉功能障碍的原因为头部外伤（n = 7）、上呼吸道感染（n = 7）和慢性鼻窦炎（n = 7）。201 .单侧给嗅裂tlcl， 24 h后行SPECT-CT检查。分离的MRI图像与SPECT图像合并。嗅觉迁移还与通过MRI图像确定的嗅球体积以及通过T&T嗅术测量的气味识别阈值相关。嗅觉受损患者鼻201 - tl向嗅球的迁移明显低于健康志愿者。当包括所有受试者时，201Tl向嗅球的迁移与T&T嗅探法获得的气味识别阈值显著相关，并与MRI图像确定的嗅球体积相关。评估201Tl向嗅球的迁移是评估嗅觉受损患者嗅神经连通性的新方法。
The aim of this study was to assess whether migration of thallium-201 (201Tl) to the olfactory bulb were reduced in patients with olfactory impairments in comparison to healthy volunteers after nasal administration of 201Tl. 10 healthy volunteers and 21 patients enrolled in the study (19 males and 12 females; 26–71 years old). The causes of olfactory dysfunction in the patients were head trauma (n = 7), upper respiratory tract infection (n = 7), and chronic rhinosinusitis (n = 7). 201TlCl was administered unilaterally to the olfactory cleft, and SPECT-CT was conducted 24 h later. Separate MRI images were merged with the SPECT images. 201Tl olfactory migration was also correlated with the volume of the olfactory bulb determined from MRI images, as well as with odor recognition thresholds measured by using T&T olfactometry. Nasal 201Tl migration to the olfactory bulb was significantly lower in the olfactory-impaired patients than in healthy volunteers. The migration of 201Tl to the olfactory bulb was significantly correlated with odor recognition thresholds obtained with T&T olfactometry and correlated with the volume of the olfactory bulb determined from MRI images when all subjects were included. Assessment of the 201Tl migration to the olfactory bulb was the new method for the evaluation of the olfactory nerve connectivity in patients with impaired olfaction.
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影响因子：
5.3
作者：
Rochefort, C;Gheusi, G;Lledo, PM
通讯作者：
Lledo, PM
影响因子：
3.1
作者：
Kanayama, Y;Enomoto, S;Amano, R
通讯作者：
Amano, R
DOI：
10.1007/bf00453761
发表时间：
1986-01-01
期刊：
ARCHIVES OF OTO-RHINO-LARYNGOLOGY
影响因子：
--
作者：
HASEGAWA, S;YAMAGISHI, M;NAKANO, Y
通讯作者：
NAKANO, Y
影响因子：
3.5
作者：
Shiga, Hideaki;Kinoshita, Yayoi;Miwa, Takaki
通讯作者：
Miwa, Takaki
影响因子：
3.3
作者：
MAIR, RG;GESTELAND, RC;BLANK, DL
通讯作者：
BLANK, DL