Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential behavioral manipulation genes and a possible major role for enterotoxins.
Ant-infecting Ophiocordyceps genomes reveal a high diversity of potential behavioral manipulation genes and a possible major role for enterotoxins.
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DOI：
10.1038/s41598-017-12863-w
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发表时间：
2017-10-02
影响因子：
4.6
通讯作者：
Hughes DP
中科院分区：
文献类型：
--
作者：
de Bekker C;Ohm RA;Evans HC;Brachmann A;Hughes DP
揭示真菌昆虫病原菌的致病机制可以获得很多信息。特别有趣的是真菌寄生虫，它们可以操纵昆虫的行为，因为据推测，它们分泌了大量的生物活性化合物。为了更深入地了解它们的策略，我们比较了来自三个物种复合体的五种感染蚂蚁的Ophiocorphae物种的基因组。这些物种是在三大洲收集的，来自五种不同的蚂蚁物种，它们诱导不同程度的操纵。相当数量的（小）分泌和致病性相关的蛋白质，只发现在这些蚂蚁操纵的Ophiocorphic物种，而不是在其他子囊菌。然而，这些蛋白质中很少有保守的，这表明已经进化出了几种不同的行为改变方法。这进一步支持了一个相对较快的进化先前报道的候选人操纵基因与咬的行为。此外，次级代谢物集群，激活过程中的叮咬行为，出现保守的物种复杂，但不超越。这些操纵寄生虫和它们各自的宿主之间的独立共同进化可能因此导致了相当多样化的策略来改变行为。我们的数据表明，专门的，分泌的肠毒素可能在这些战略之一发挥了重要作用。
Much can be gained from revealing the mechanisms fungal entomopathogens employ. Especially intriguing are fungal parasites that manipulate insect behavior because, presumably, they secrete a wealth of bioactive compounds. To gain more insight into their strategies, we compared the genomes of five ant-infecting Ophiocordyceps species from three species complexes. These species were collected across three continents, from five different ant species in which they induce different levels of manipulation. A considerable number of (small) secreted and pathogenicity-related proteins were only found in these ant-manipulating Ophiocordyceps species, and not in other ascomycetes. However, few of those proteins were conserved among them, suggesting that several different methods of behavior modification have evolved. This is further supported by a relatively fast evolution of previously reported candidate manipulation genes associated with biting behavior. Moreover, secondary metabolite clusters, activated during biting behavior, appeared conserved within a species complex, but not beyond. The independent co-evolution between these manipulating parasites and their respective hosts might thus have led to rather diverse strategies to alter behavior. Our data indicate that specialized, secreted enterotoxins may play a major role in one of these strategies.
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影响因子：
10.7
作者：
Castresana, J
通讯作者：
Castresana, J
影响因子：
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作者：
Jurka, J;Kapitonov, VV;Walichiewicz, J
通讯作者：
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作者：
de Bekker C;Quevillon LE;Smith PB;Fleming KR;Ghosh D;Patterson AD;Hughes DP
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影响因子：
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作者：
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通讯作者：
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