A randomized clinical trial evaluating choroidal blood flow and morphology after conventional and pattern scan laser panretinal photocoagulation.
A randomized clinical trial evaluating choroidal blood flow and morphology after conventional and pattern scan laser panretinal photocoagulation.
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DOI：
10.1038/s41598-018-32487-y
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发表时间：
2018-09-20
影响因子：
4.6
通讯作者：
Terasaki H
中科院分区：
文献类型：
--
作者：
Mikoshiba Y;Iwase T;Ueno Y;Yamamoto K;Ra E;Terasaki H
我们前瞻性地观察了39只重度非增殖性糖尿病视网膜病变(S-NPDR)患者行全视网膜光凝(PRP)后脉络膜血流和形态的变化。常规激光PRP 17眼，模式扫描激光(PASCAL)22眼。分别于治疗前、治疗后1、4、8、12周用激光散斑血流图检测脉络膜血流，用光学相干断层扫描测量脉络膜下厚度(SFCT)。12周时黄斑区脉络膜平均模糊率在常规激光治疗组和帕斯卡激光治疗组分别降至基线水平的86.4%和85.7%(P = 0.001，P <； 0.001)。两组在PRP后1周SFCT显著升高，第8周显著降低(分别为P = 0.001，P <； 0.001)。PRP后各时间点常规激光组与PASCAL组的MBR/SFCT比值差异无统计学意义。结果表明，适当的PRP治疗，即使是Pascal方法，也会减少脉络膜血流量和脉络膜形态成分。
We prospectively investigated the changes in choroidal blood flow and morphology after panretinal photocoagulation (PRP) in 39 eyes with severe nonproliferative diabetic retinopathy (S-NPDR). Seventeen eyes underwent PRP by conventional laser and 22 eyes underwent pattern scan laser (PASCAL). The choroidal blood flow was assessed by laser speckle flowgraphy, and the subfoveal choroidal thickness (SFCT) was measured with optical coherence tomography before and 1, 4, 8, and 12 weeks after the two types of PRP treatments. The choroidal mean blur rate (MBR) at the macular region was significantly reduced to 86.4% of the baseline level in the conventional laser group and 85.7% in the PASCAL group at Week 12 (P = 0.001, P < 0.001, respectively). The SFCT was significantly increased at 1 week following PRP but it was significantly reduced at Week 8 (P = 0.001, P < 0.001, respectively) in both groups. The differences in the ratio of the MBR and the SFCT was not significant between the conventional laser and PASCAL groups at any time after PRP. The results suggest that appropriate PRP treatments even by the PASCAL method will reduce the choroidal blood flow and the choroidal morphological components.
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影响因子：
13.7
作者：
Branchini LA;Adhi M;Regatieri CV;Nandakumar N;Liu JJ;Laver N;Fujimoto JG;Duker JS
通讯作者：
Duker JS
DOI：
10.2147/opth.s22093
发表时间：
2011
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Aizawa N;Yokoyama Y;Chiba N;Omodaka K;Yasuda M;Otomo T;Nakamura M;Fuse N;Nakazawa T
通讯作者：
Nakazawa T
影响因子：
4.4
作者：
Nagahara, Miyuki;Tamaki, Yasuhiro;Araie, Makoto
通讯作者：
Araie, Makoto
影响因子：
13.7
作者：
Chew, EY;Ferris, FL III;Schachat, AP
通讯作者：
Schachat, AP
影响因子：
3.9
作者：
Muqit, M. M. K.;Marcellino, G. R.;Stanga, P. E.
通讯作者：
Stanga, P. E.