Different patterns of age-related central olfactory decline in men and women as quantified by olfactory fMRI.
Different patterns of age-related central olfactory decline in men and women as quantified by olfactory fMRI.
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DOI：
10.18632/oncotarget.16977
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发表时间：
2017-10-03
期刊：
影响因子：
--
通讯作者：
Yang QX
中科院分区：
文献类型：
--
作者：
Martinez B;Karunanayaka P;Wang J;Tobia MJ;Vasavada M;Eslinger PJ;Yang QX
与年龄相关的嗅觉衰退或老嗅觉是一种普遍存在的疾病，可能对生活质量和安全造成毁灭性后果。尽管有明确的证据表明这种下降，但尚不清楚老花眼是否具有性别依赖性，以及是否是由于中枢或外周嗅觉系统恶化所致。因此，本研究的目标是使用嗅觉功能 MRI (fMRI) 调查嗅觉衰退的神经功能基础，并检查 37 名（18 名女性，19 名男性）健康老年参与者的嗅觉衰退与年龄和性别的关系。嗅觉功能磁共振成像范式利用独特的气味+视觉和仅视觉条件分别对比外周到中枢和中枢到中枢的嗅觉处理。年龄与嗅觉相关区域的功能磁共振成像激活呈负相关。在所有目标区域的男性参与者中都可以发现显着的衰老影响。然而，女性参与者表现出不同的功能衰退模式。扩展统一结构方程模型（euSEM）分析显示，男性和女性参与者之间的有效功能连接特征截然不同，女性表现出自上而下的机制来抵消与年龄相关的嗅觉激活下降。我们的结果支持这样的假设：中枢嗅觉系统参与与年龄相关的嗅觉衰退，而女性对与年龄相关的嗅觉衰退的恢复能力可能是由于她们丰富的嗅觉网络有效连接。
Age-related olfactory decline, or presbyosmia, is a prevalent condition with potentially devastating consequences on both quality of life and safety. Despite clear evidence for this decline, it is unknown whether presbyosmia is sex-dependent and also whether it is due to central or peripheral olfactory system deterioration. Therefore, the goals of this study were to investigate the neurofunctional substrate of olfactory decline and examine its relationship to age and sex in thirty-seven (18 women, 19 men) healthy older participants using olfactory functional MRI (fMRI). The olfactory fMRI paradigm utilized unique odor+visual and visual-only conditions to contrast peripheral-to-central and central-to-central olfactory processing, respectively. Age was negatively correlated with fMRI activation in olfactory-related regions. Significant aging effects were identifiable in male participants in all target regions. Female participants, however, showed a different pattern of functional decline. Extended unified structural equation modeling (euSEM) analysis revealed that the effective functional connectivity profile was drastically different between male and female participants, with females manifesting a top-down mechanism to offset age-related olfactory activation decline. Our results support the hypotheses that the central olfactory system is involved in age-related olfactory decline, and that resilience to age-related olfactory decline in women may be due to their profuse olfactory network effective connectivity.
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DOI：
10.1523/jneurosci.0154-12.2012
发表时间：
2012-06-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Igarashi KM;Ieki N;An M;Yamaguchi Y;Nagayama S;Kobayakawa K;Kobayakawa R;Tanifuji M;Sakano H;Chen WR;Mori K
通讯作者：
Mori K
影响因子：
2.9
作者：
DOTY, RL;SHAMAN, P;DANN, M
通讯作者：
DANN, M
影响因子：
2.9
作者：
Cerf-Ducastel, B;Murphy, C
通讯作者：
Murphy, C
影响因子：
5.7
作者：
Ferdon, S;Murphy, C
通讯作者：
Murphy, C
DOI：
10.1196/annals.1280.035
发表时间：
2003-01-01
期刊：
EMOTIONS INSIDE OUT
影响因子：
--
作者：
Heining, M;Young, AW;Phillips, ML
通讯作者：
Phillips, ML