Identification of the Neural Correlates Underlying Conflict Resolution Performance Using a Rodent Analogue of the Stroop Tests.
Identification of the Neural Correlates Underlying Conflict Resolution Performance Using a Rodent Analogue of the Stroop Tests.
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DOI：
10.1016/j.neuroscience.2023.05.024
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发表时间：
2023-08-01
期刊：
影响因子：
3.3
通讯作者：
Lelos, M. J.
中科院分区：
文献类型：
--
作者：
Clinch, S. P.;Busse, M.;Griffiths, J.;Rosser, A. E.;Lelos, M. J.
我们探索了在啮齿动物版本的Stroop任务中激活的大脑区域。我们的数据揭示了皮质和纹状体区域的新参与。背内侧纹状体、边缘下皮质和压后皮质也有牵连。这些数据对患有神经系统疾病的人有影响。Stroop测试是一种广泛使用的神经心理学测试，用于测量注意力和冲突解决能力，它显示了对一系列疾病的敏感性，包括阿尔茨海默氏症、帕金森氏症和亨廷顿氏症。Stroop测试的啮齿动物模拟物，反应冲突任务（rRCT），允许系统地调查在该测试中支撑性能的神经系统。很少有人知道基底神经节在这个神经过程中的参与。本研究的目的是使用随机对照试验，以确定是否纹状体亚区招募冲突解决过程中。为了实现这一点，大鼠暴露于一致或不一致的刺激rRCT和立即早期基因Zif268的表达模式进行了分析，在整个皮质，海马和基底神经节亚区。结果证实了先前报道的参与前额叶皮层和海马区，以及确定一个特定的作用，为dysgranular（但不是颗粒）的压后皮层在冲突解决。最后，性能的准确性与减少背内侧纹状体的神经激活显着相关。基底神经节参与这一神经过程以前没有报道。这些数据表明，冲突解决的认知过程不仅需要前额叶皮层区域，但也招募了颗粒异常的压后皮层和内侧区的新纹状体。这些数据对理解神经解剖学变化具有重要意义，这些变化是神经系统疾病患者Stroop表现受损的基础。
We explored the brain regions activated in a rodent version of the Stroop task. Our data revealed novel involvement of cortical and striatal regions. The dorsomedial striatum, infralimbic and retrosplenial cortices are implicated. These data have implications for people with neurological conditions. The Stroop test is a widely used neuropsychological test measuring attention and conflict resolution, which shows sensitivity across a range of diseases, including Alzheimer’s, Parkinson’s and Huntington’s diseases. A rodent analogue of the Stroop test, the Response-Conflict task (rRCT), allows for systematic investigation of the neural systems underpinning performance in this test. Little is known about the involvement of the basal ganglia in this neural process. The aim of this study was to use the rRCT to determine whether striatal subregions are recruited during conflict resolution processing. To achieve this, rats were exposed to Congruent or Incongruent stimuli in the rRCT and the expression patterns of the immediate early gene Zif268 were analysed throughout cortical, hippocampal and basal ganglia subregions. The results confirmed the previously reported involvement of prefrontal cortical and hippocampal regions, as well as identifying a specific role for the dysgranular (but not granular) retrosplenial cortex in conflict resolution. Finally, performance accuracy correlated significantly with reduced neural activation in the dorsomedial striatum. Involvement of the basal ganglia in this neural process has not previously been reported. These data demonstrate that the cognitive process of conflict resolution requires not only prefrontal cortical regions, but also recruits the dysgranular retrosplenial cortex and the medial region of the neostriatum. These data have implications for understanding the neuroanatomical changes that underpin impaired Stroop performance in people with neurological disorders.
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影响因子：
3.3
作者：
Haddon, J. E.;Killcross, S.
通讯作者：
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影响因子：
2
作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1196/annals.1390.000
发表时间：
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期刊：
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影响因子：
--
作者：
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通讯作者：
Killcross, Simon
影响因子：
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作者：
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通讯作者：
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