Multifactorial analysis of changes in body mass index across the adult life course: a study with 65 years of follow-up.
Multifactorial analysis of changes in body mass index across the adult life course: a study with 65 years of follow-up.
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DOI：
10.1038/ijo.2013.204
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发表时间：
2014-08
影响因子：
4.9
通讯作者：
Pedersen, N. L.
中科院分区：
文献类型：
--
作者：
Dahl, A. K.;Reynolds, C. A.;Fall, T.;Magnusson, P. K. E.;Pedersen, N. L.
虽然肥胖对健康的负面影响是众所周知的，但大多数成年人在一生中都会增加体重。体重指数（BMI）的普遍增加主要被认为是源于行为和环境的变化，但很少有研究评估这些因素对存在遗传风险的BMI变化的影响。我们的目的是研究65岁以上BMI变化的多因素影响。总共有6，130名来自TwinGene的参与者，他们进行了多达5次评估，536名来自瑞典收养/双胞胎衰老研究，他们进行了多达12次评估，年龄超过65岁。采用生长模型评估生活方式因素、出生队列、心脏代谢疾病和基于32个单核苷酸多态性的个体肥胖遗传风险评分对BMI变化的影响。对于男性和女性来说，BMI从成年早期到65岁都在增加，之后增加趋于平稳; BMI在80岁之后下降。较高的肥胖遗传风险评分、1925年以后出生和心脏代谢疾病与较高的平均BMI和65岁以前BMI的急剧增加相关。在男性中，很少有因素影响晚年的BMI轨迹，而对于女性，2型糖尿病和痴呆症与65岁后BMI的急剧下降有关。成年后期的BMI有两个转折点，一个在65岁，一个在80岁。与中年BMI增加相关的因素与65岁后BMI增加无关。这些发现表明，BMI变化的原因和后果在整个生命周期中是不同的。目前的健康建议需要相应调整。
Although the negative consequences on health of being obese are well known, most adults gain weight across the life span. The general increase in body mass index (BMI) is mainly considered to originate from behavioral and environmental changes, but few studies have evaluated the influence of these factors on change in BMI in the presence of genetic risk. We aimed to study the influence of multifactorial causes of change in BMI, over 65 years. Totally, 6,130 participants from TwinGene, who had up to 5 assessments, and 536 from the Swedish Adoption/Twin Study of Aging, who had up to 12 assessments, ranging over 65 years were included. The influence of lifestyle factors, birth cohort, cardiometabolic diseases, and an individual obesity genetic risk score based on 32 single nucleotide polymorphisms on change in BMI was evaluated with a growth model. For both sexes, BMI increased from early adulthood to age 65 years, after which the increase leveled off; BMI declined after age 80 years. A higher obesity genetic risk score, birth after 1925, and cardiometabolic diseases were associated with higher average BMI and a steeper increase in BMI prior to age 65 years. Among men, few factors were identified that influence BMI trajectories in late life, while for women, type 2 diabetes mellitus and dementia were associated with a steeper decrease in BMI after the age of 65 years. There are two turning points in BMI in late adulthood, one at age 65 years and one at age 80 years. Factors associated with an increase in BMI in midlife, were not associated with an increase in BMI after the age of 65 years. These findings indicate that the causes and consequences of change in BMI differ across the life span. Current health recommendations need to be adjusted accordingly.
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影响因子：
168.9
作者：
Renehan, Andrew G.;Tyson, Margaret;Zwahlen, Marcel
通讯作者：
Zwahlen, Marcel
影响因子：
1.9
作者：
Finkel, D;Pedersen, NL
通讯作者：
Pedersen, NL
DOI：
10.1001/archpediatrics.2012.131
发表时间：
2012-06-01
影响因子：
--
作者：
Belsky, Daniel W.;Moffitt, Terrie E.;Caspi, Avshalom
通讯作者：
Caspi, Avshalom
影响因子：
5
作者：
Corrada, MM;Kawas, CH;Paganini-Hill, A
通讯作者：
Paganini-Hill, A
童年时期 BMI 的遗传力不断增加，与 FTO 基因的关联性更强
影响因子：
6.9
作者：
Haworth, Claire M. A.;Carnell, Susan;Wardle, Jane
通讯作者：
Wardle, Jane