Aerobic exercise training and neurocognitive function in cognitively normal older adults: A one-year randomized controlled trial.
Aerobic exercise training and neurocognitive function in cognitively normal older adults: A one-year randomized controlled trial.
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DOI：
10.1111/joim.13534
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发表时间：
2022-11
影响因子：
11.1
通讯作者：
Zhang, Rong
中科院分区：
文献类型：
--
作者：
Tarumi, Takashi;Patel, Neena R.;Tomoto, Tsubasa;Pasha, Evan;Khan, Ayaz M.;Kostroske, Kayla;Riley, Jonathan;Tinajero, Cynthia D.;Wang, Ciwen;Hynan, Linda S.;Rodrigue, Karen M.;Kennedy, Kristen M.;Park, Denise C.;Zhang, Rong
关键词：
目前的证据是不一致的有氧运动训练的好处，预防或减轻老年人与年龄相关的认知能力下降。研究一年渐进式中高强度有氧运动干预对久坐但其他方面健康的老年人的认知功能、脑容量和皮质厚度的影响。我们将73名老年人随机分为为期一年的有氧运动或拉伸和调色（主动控制）计划。主要结果是从8个神经心理学测试计算的认知综合评分，包括归纳推理，长期和工作记忆，执行功能和处理速度。次要结果是通过MRI评估的脑体积和皮质厚度，以及通过峰值摄氧量（VO2）测量的心肺适应性。一年的有氧运动使峰值VO2增加了约10%（p<0.001），而拉伸没有改变（p=0.241）。有氧运动组和拉伸运动组的认知综合评分均有所增加（时间效应p<0.001），但未观察到组间差异。随着时间的推移，两组的总脑体积（p<0.001）和平均皮质厚度（p=0.001）都有所下降，而拉伸组海马体积的减少小于有氧组（相互作用p=0.040）。在所有参与者中，峰值VO2的改善与认知综合评分（r=0.282，p=0.042）和下顶叶区域皮质厚度（p=0.016）的增加呈正相关。为期一年的有氧运动和拉伸干预改善了认知能力，但并没有阻止久坐的健康老年人与年龄相关的脑容量损失。呼吸适应性增益与认知能力和区域皮质厚度呈正相关。
Current evidence is inconsistent on the benefits of aerobic exercise training for preventing or attenuating age-related cognitive decline in older adults. To investigate the effects of a one-year progressive, moderate-to-high intensity aerobic exercise intervention on cognitive function, brain volume, and cortical thickness in sedentary but otherwise healthy older adults. We randomized 73 older adults to a one-year aerobic exercise or stretching-and-toning (active control) program. The primary outcome was a cognitive composite score calculated from eight neuropsychological tests encompassing inductive reasoning, long-term and working memory, executive function, and processing speed. Secondary outcomes were brain volume and cortical thickness assessed by MRI, and cardiorespiratory fitness measured by peak oxygen uptake (VO2). One-year aerobic exercise increased peak VO2 by ~10% (p<0.001) while it did not change with stretching (p=0.241). Cognitive composite scores increased in both the aerobic and stretching groups (p<0.001 for time effect), although no group difference was observed. Total brain volume (p<0.001) and mean cortical thickness (p=0.001) decreased in both groups over time while the reduction in hippocampal volume was smaller in the stretching group compared with the aerobic group (p=0.040 for interaction). Across all participants, improvement in peak VO2 was positively correlated with increases in cognitive composite score (r=0.282, p=0.042) and regional cortical thickness at the inferior parietal lobe (p=0.016). One-year aerobic exercise and stretching interventions improved cognitive performance but did not prevent age-related brain volume loss in sedentary healthy older adults. Cardiorespiratory fitness gain was positively correlated with cognitive performance and regional cortical thickness.
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影响因子：
1.3
作者：
BECHTOLDT, HP;FOGEL, ML;BENTON, AL
通讯作者：
BENTON, AL
DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
3.7
作者：
Curlik, Daniel M., II;Maeng, Lisa Y.;Shors, Tracey J.
通讯作者：
Shors, Tracey J.
影响因子：
7.2
作者：
Gates, Nicola;Singh, Maria A. Fiatarone;Valenzuela, Michael
通讯作者：
Valenzuela, Michael
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.