Intersecting kinematic encoding and readout of intention in autism.
Intersecting kinematic encoding and readout of intention in autism.
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DOI：
10.1073/pnas.2114648119
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发表时间：
2022-02-01
影响因子：
11.1
通讯作者：
Becchio C
中科院分区：
文献类型：
--
作者：
Montobbio N;Cavallo A;Albergo D;Ansuini C;Battaglia F;Podda J;Nobili L;Panzeri S;Becchio C
研究意图阅读的一个主要挑战是高运动变异性。跨试验进行的分析提供了对平均发生的情况的见解;然而，它们可能会模糊个体观察者如何阅读个体运动中的意图信息。我们结合了运动跟踪、心理物理学和计算分析，以单次试验分辨率来检查自闭症谱系障碍（ASD）的意图阅读。结果显示，一个相当大的部分ASD观察员可以识别意图信息的变化ASD（但不是在典型的发展）运动学，但他们仍然无法提取编码的意图信息。这种方法不仅增强了我们对自闭症儿童阅读的基本理解，而且为合理设计训练程序以提高对他人行为的阅读提供了潜在的途径。患有自闭症谱系障碍（ASD）的观察者发现很难从动作中解读意图。然而，这些困难的计算基础是未知的。这些困难是否反映了意图读出缺陷，或者它们更可能植根于典型和ASD运动学之间的运动学（不）相似性？我们结合了运动跟踪，心理物理学和计算分析，以揭示在典型发育（TD）儿童（n = 35）和ASD儿童（n = 35）中的单次试验意图读出计算，这些儿童观察TD儿童和ASD儿童的行为。平均意图歧视性能高于TD观察员的机会，但不是ASD观察员。然而，单次试验分析表明，TD和ASD观察员读取单次试验的运动学变化。TD读者能够更好地确定意图信息的运动学特征，在观察TD行动;相反，ASD读者能够更好地确定意图信息的功能，在观察ASD行动。至关重要的是，虽然TD观察者通常能够提取运动学中编码的意图信息，但自闭症患者却无法做到这一点。这些结果扩展了现有的概念，心理阅读在ASD的建议，意图阅读的困难反映了互动失败，根源于TD和ASD运动学之间的运动学差异（在功能识别的水平），和个人读出赤字（在信息提取的水平），伴随着整体降低的灵敏度的意图读出单次试验的运动学变化。
A major challenge in studying intention reading is high motor variability. Analyses conducted across trials provide insights into what happens on average; however, they may obscure how individual observers read intention information in individual movements. We combined motion tracking, psychophysics, and computational analyses to examine intention reading in autism spectrum disorders (ASDs) with single-trial resolution. Results revealed that a sizeable fraction of ASD observers can identify intention-informative variations in ASD (but not in typically developing) movement kinematics, but they are nonetheless unable to extract the encoded intention information. This approach not only enhances our basic understanding of mind reading in ASD but also provides potential avenues for the rational design of training procedures to improve the reading of others’ actions. Observers with autism spectrum disorders (ASDs) find it difficult to read intentions from movements. However, the computational bases of these difficulties are unknown. Do these difficulties reflect an intention readout deficit, or are they more likely rooted in kinematic (dis-)similarities between typical and ASD kinematics? We combined motion tracking, psychophysics, and computational analyses to uncover single-trial intention readout computations in typically developing (TD) children (n = 35) and children with ASD (n = 35) who observed actions performed by TD children and children with ASD. Average intention discrimination performance was above chance for TD observers but not for ASD observers. However, single-trial analysis showed that both TD and ASD observers read single-trial variations in movement kinematics. TD readers were better able to identify intention-informative kinematic features during observation of TD actions; conversely, ASD readers were better able to identify intention-informative features during observation of ASD actions. Crucially, while TD observers were generally able to extract the intention information encoded in movement kinematics, those with autism were unable to do so. These results extend existing conceptions of mind reading in ASD by suggesting that intention reading difficulties reflect both an interaction failure, rooted in kinematic dissimilarity between TD and ASD kinematics (at the level of feature identification), and an individual readout deficit (at the level of information extraction), accompanied by an overall reduced sensitivity of intention readout to single-trial variations in movement kinematics.
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DOI：
10.1016/j.cub.2020.08.104
发表时间：
2020-12-07
期刊：
Current biology : CB
影响因子：
--
作者：
Patri JF;Cavallo A;Pullar K;Soriano M;Valente M;Koul A;Avenanti A;Panzeri S;Becchio C
通讯作者：
Becchio C
影响因子：
5.4
作者：
de Cruys, Sander Van;Evers, Kris;Wagemans, Johan
通讯作者：
Wagemans, Johan
影响因子：
2
作者：
Latash, Mark L.
通讯作者：
Latash, Mark L.
DOI：
10.1073/pnas.2011311117
发表时间：
2020-11-03
影响因子：
11.1
作者：
Casartelli L;Federici A;Fumagalli L;Cesareo A;Nicoli M;Ronconi L;Vitale A;Molteni M;Rizzolatti G;Sinigaglia C
通讯作者：
Sinigaglia C
影响因子：
1.8
作者：
Kim, Ji-Hyun
通讯作者：
Kim, Ji-Hyun