Targeting Neuronal Networks with Combined Drug and Stimulation Paradigms Guided by Neuroimaging to Treat Brain Disorders.
Targeting Neuronal Networks with Combined Drug and Stimulation Paradigms Guided by Neuroimaging to Treat Brain Disorders.
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DOI：
10.1177/1073858415592377
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Blumenfeld H
中科院分区：
文献类型：
--
作者：
Faingold CL;Blumenfeld H
通过关注神经元网络，利用由神经成像引导的组合药理学和刺激范例，可以实现脑疾病的改善治疗。调节正常大脑功能（如听觉）的神经元网络与其他网络相互作用，这很重要，但通常被忽视。网络互动的变化往往是大脑疾病的基础，包括癫痫。“条件性多感受性”（CMR）脑区域（例如，脑干网状结构和杏仁核）在介导促进网络相互作用的神经可塑性变化中至关重要。CMR神经元接收多个输入，但由于环境和行为状态的变化而表现出广泛的反应变异性，并且对增加或抑制GABA介导的抑制的试剂非常敏感。增强的CMR神经元反应性导致表达的紧急属性-非线性事件-导致网络自组织。确定大脑疾病机制需要动物模型的行为和神经解剖学基板的人类疾病确定的神经成像。然而，并非在网络操作期间激活的所有站点都是该操作所必需的。其他活性位点是辅助性的，因为它们的阻断不会改变网络功能。Requirements网络站点表现出药物和刺激疗法的关键目标的紧急属性。改善脑部疾病的治疗应该包括在神经影像学指导下，结合药理学和刺激疗法，通过靶向特定的网络神经元来纠正网络故障。
Improved therapy of brain disorders can be achieved by focusing on neuronal networks, utilizing combined pharmacological and stimulation paradigms guided by neuroimaging. Neuronal networks that mediate normal brain functions, such as hearing, interact with other networks, which is important but commonly neglected. Network interaction changes often underlie brain disorders, including epilepsy. “Conditional multireceptive” (CMR) brain areas (e.g., brainstem reticular formation and amygdala) are critical in mediating neuroplastic changes that facilitate network interactions. CMR neurons receive multiple inputs but exhibit extensive response variability due to milieu and behavioral state changes and are exquisitely sensitive to agents that increase or inhibit GABA-mediated inhibition. Enhanced CMR neuronal responsiveness leads to expression of emergent properties—nonlinear events—resulting from network self-organization. Determining brain disorder mechanisms requires animals that model behaviors and neuroanatomical substrates of human disorders identified by neuroimaging. However, not all sites activated during network operation are requisite for that operation. Other active sites are ancillary, because their blockade does not alter network function. Requisite network sites exhibit emergent properties that are critical targets for pharmacological and stimulation therapies. Improved treatment of brain disorders should involve combined pharmacological and stimulation therapies, guided by neuroimaging, to correct network malfunctions by targeting specific network neurons.
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DOI：
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发表时间：
2012-05-18
期刊：
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影响因子：
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DOI：
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发表时间：
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期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
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作者：
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