Lesions of suprachiasmatic nucleus modify sleep structure but do not alter the total amount of daily sleep in rats
Lesions of suprachiasmatic nucleus modify sleep structure but do not alter the total amount of daily sleep in rats
复制标题
视交叉上核损伤会改变大鼠的睡眠结构，但不会改变每日睡眠总量
DOI：
10.1111/j.1479-8425.2012.00572.x
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发表时间：
2012-10
影响因子：
1.1
通讯作者：
Qu WM
中科院分区：
文献类型：
--
作者：
Liu XG;Zhang BJ;Xu XH;Huang ZL;Qu WM
视交叉上核（SCN）是一个主要的昼夜节律起搏器。它调节许多生理过程的24小时定时，包括睡眠和清醒。双侧SCN损伤后，睡眠-觉醒周期的昼夜节律完全消失，但睡眠-觉醒曲线的特征尚不清楚。在本研究中，双侧视交叉上核病变（SCNX）在大鼠中创建，以确定SCNX对睡眠-觉醒曲线的影响，包括发作次数、每个阶段的平均持续时间和阶段之间的转换次数。虽然双侧SCN病变完全消除了睡眠-觉醒周期的昼夜节律，但病变前后每日睡眠或觉醒总量无显著变化。然而，SCN损伤大鼠在黑暗期觉醒和非快速眼动（NREM）睡眠的发作次数增加，而在光照期则减少。平均清醒持续时间显着下降，在黑暗时期和增加在光明时期。NREM睡眠和觉醒之间的转换次数在黑暗时期增加，在光明时期减少。观察24小时后，NREM睡眠功率密度和总发作次数、转换次数和平均持续时间与假手术对照组无显著差异。这些结果表明，视交叉上核的损害并没有改变每天的睡眠总量，但确实改变了结构的睡眠觉醒配置文件。
The suprachiasmatic nucleus (SCN) is a master circadian pacemaker. It regulates the 24 h timing of many physiological processes, including sleeping and waking. After bilateral SCN lesions, the circadian rhythm of the sleep wake cycle was completely eliminated, but the characteristics of the sleep wake profile were not well clarified. In the present study, bilateral suprachiasmatic nucleus lesions (SCNX) were created in rats to determine the effects of SCNX on the sleep-wake profile in terms of number of episodes, mean duration of each stage and number of transitions between stages. Although bilateral SCN lesions completely eliminated the circadian rhythm in the sleepwake cycle, there was no significant change in the total amount of daily sleep or wakefulness before and after lesions. However, the SCN-lesioned rats exhibited anincreased episode number of wake and non-rapid eye movement (NREM) sleep during dark period and a decreased one during light period. The mean duration of wakefulness decreased significantly during the dark period and increased during the light period. The number of transitions between NREM sleep and wakefulness increased during the dark period and decreased during the light period. The NREM sleep power density and total number of episodes, number of transitions, and mean duration were not significantly different from those of sham controls when viewed over 24 h. These results indicate that lesions of suprachiasmatic nucleus did not alter the total amount of daily sleep but did modify the structure of sleepwake profiles in rats.
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影响因子：
2.9
作者：
IBUKA, N;KAWAMURA, H
通讯作者：
KAWAMURA, H
影响因子：
25
作者：
Gooley, JJ;Lu, J;Saper, CB
通讯作者：
Saper, CB
DOI：
10.1073/pnas.0810926105
发表时间：
2008-12-16
影响因子：
11.1
作者：
Oishi, Yo;Huang, Zhi-Li;Hayaishi, Osamu
通讯作者：
Hayaishi, Osamu
影响因子：
25
作者：
Huang, ZL;Qu, WM;Hayaishi, O
通讯作者：
Hayaishi, O
影响因子：
25
作者：
Deboer, T;Vansteensel, MJ;Meijer, JH
通讯作者：
Meijer, JH