Site-specific quantification of bone quality using highly nonlinear solitary waves.
Site-specific quantification of bone quality using highly nonlinear solitary waves.
复制标题
使用高度非线性孤立波对骨质量进行特定部位的量化。
DOI：
10.1115/1.4007364
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
E. Ebramzadeh
中科院分区：
文献类型：
--
作者：
Jinkyu Yang;S. Sangiorgio;S. Borkowski;C. Silvestro;L. De Nardo;C. Daraio;E. Ebramzadeh
骨质疏松症是一个众所周知的问题，影响着全世界数百万人。以有效、高效且经济实惠的方式诊断问题并识别面临风险的个人的能力至关重要。骨机械特性的特定部位评估是必要的，不仅在骨折风险评估过程中，而且对于其他应用也可能是可取的，例如在脊柱和关节置换手术期间做出术中决策。本研究评估使用一维颗粒晶体传感器通过直接机械接触测量选定位置的骨骼弹性特性。粒状晶体由紧密堆积的粒子链组成，这些粒子根据赫兹接触定律相互作用。这种链代表了以紧凑孤立波的形式生成和传播高度非线性声信号的最简单系统之一。首先，我们使用合成松质骨替代物研究了传感器对已知骨密度变化的敏感性，代表了从健康到骨质疏松的临床骨质量。一旦建立了信号响应和已知骨骼特性之间的关系，传感器就被用来评估十个人类尸体标本的骨骼质量。然后通过将传感器测量值与使用双能 X 射线吸收测定法 (DEXA) 获得的骨矿物质密度 (BMD) 进行比较，研究传感器的功效和准确性。结果表明，所提出的技术能够检测骨质量的差异。在不暴露于辐射的情况下测量特定部位特性的能力有可能进一步开发用于临床应用。
Osteoporosis is a well recognized problem affecting millions of individuals worldwide. The ability to diagnose problems in an effective, efficient, and affordable manner and identify individuals at risk is essential. Site-specific assessment of bone mechanical properties is necessary, not only in the process of fracture risk assessment, but may also be desirable for other applications, such as making intraoperative decisions during spine and joint replacement surgeries. The present study evaluates the use of a one-dimensional granular crystal sensor to measure the elastic properties of bone at selected locations via direct mechanical contact. The granular crystal is composed of a tightly packed chain of particles that interact according to the Hertzian contact law. Such chains represent one of the simplest systems to generate and propagate highly nonlinear acoustic signals in the form of compact solitary waves. First, we investigated the sensitivity of the sensor to known variations in bone density using a synthetic cancellous bone substitute, representing clinical bone quality ranging from healthy to osteoporotic. Once the relationship between the signal response and known bone properties was established, the sensor was used to assess the bone quality of ten human cadaveric specimens. The efficacy and accuracy of the sensor was then investigated by comparing the sensor measurements with the bone mineral density (BMD) obtained using dual-energy x-ray absorptiometry (DEXA). The results indicate that the proposed technique is capable of detecting differences in bone quality. The ability to measure site-specific properties without exposure to radiation has the potential to be further developed for clinical applications.
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影响因子：
2.4
作者：
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