Failing to forget: inhibitory-control deficits compromise memory suppression in posttraumatic stress disorder.
Failing to forget: inhibitory-control deficits compromise memory suppression in posttraumatic stress disorder.
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DOI：
10.1177/0956797615569889
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发表时间：
2015-05
影响因子：
8.2
通讯作者：
Anderson MC
中科院分区：
文献类型：
--
作者：
Catarino A;Küpper CS;Werner-Seidler A;Dalgleish T;Anderson MC
大多数人都经历过他们宁愿忘记的痛苦事件。虽然对大多数人来说，随着时间的推移，这些事件的记忆变得不那么侵扰，但那些患有创伤后应激障碍（PTSD）的人会受到生动的，反复出现的创伤记忆的折磨。这些记忆通常由日常环境中的提醒触发，可能会导致严重的痛苦和损害。我们认为，创伤后应激障碍中的侵入性记忆的困难部分来自于抑制性控制抑制情景提取的缺陷。我们通过调整思考/不思考范式来测试这一假设，以调查自然主义提醒引起的厌恶场景的自愿记忆抑制。与创伤暴露的对照组相比，PTSD患者的检索抑制明显受损。此外，在抑制性遗忘中缺陷最大的患者也是PTSD症状最严重的患者。这些结果提高了支持记忆抑制控制的前额叶机制在PTSD中受损的可能性。
Most people have experienced distressing events that they would rather forget. Although memories of such events become less intrusive with time for the majority of people, those with posttraumatic stress disorder (PTSD) are afflicted by vivid, recurrent memories of their trauma. Often triggered by reminders in the daily environment, these memories can cause severe distress and impairment. We propose that difficulties with intrusive memories in PTSD arise in part from a deficit in engaging inhibitory control to suppress episodic retrieval. We tested this hypothesis by adapting the think/no-think paradigm to investigate voluntary memory suppression of aversive scenes cued by naturalistic reminders. Retrieval suppression was compromised significantly in PTSD patients, compared with trauma-exposed control participants. Furthermore, patients with the largest deficits in suppression-induced forgetting were also those with the most severe PTSD symptoms. These results raise the possibility that prefrontal mechanisms supporting inhibitory control over memory are impaired in PTSD.
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影响因子：
2.6
作者：
Fani, Negar;Jovanovic, Tanja;Ely, Timothy D.;Bradley, Bekh;Gutman, David;Tone, Erin B.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
64.8
作者：
Anderson, MC;Green, C
通讯作者：
Green, C
DOI：
10.1027/0044-3409/a000021
发表时间：
2010
期刊：
Zeitschrift fur Psychologie
影响因子：
--
作者：
Ehlers A
通讯作者：
Ehlers A
影响因子：
4.6
作者：
Joormann J;Hertel PT;LeMoult J;Gotlib IH
通讯作者：
Gotlib IH
影响因子：
19.9
作者：
Anderson, Michael C.;Hanslmayr, Simon
通讯作者：
Hanslmayr, Simon