Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats.
Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats.
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DOI：
10.1177/0269881120937543
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Nazarian A
中科院分区：
文献类型：
--
作者：
Íbias J;Nazarian A
认知冲动的增强和由此导致的决策改变是物质使用障碍发展和维持的一个促成因素。尼古丁引起的冲动增加已经在男性和啮齿类动物中有过报道。虽然尼古丁诱发冲动的性别差异的可能性还没有被研究过。在本研究中，雄性和雌性Sprague Dawley大鼠被提交给一个延迟折扣任务，在这个任务中，连续采取了几种自我控制措施。首先给大鼠注射载药，然后给大鼠注射0.4和0.8 mg/kg的尼古丁。此后，开始用安非他酮进行慢性治疗，并再次对动物进行测试。一半的动物继续接受0.8毫克/公斤的尼古丁，而其余的动物接受尼古丁和每天30毫克/公斤的安非他酮剂量。当动物第一次接受尼古丁测试时，雌性大鼠表现出明显的尼古丁剂量依赖性冲动行为的增加，而雄性大鼠在0.8 mg/kg尼古丁的最高剂量下，只表现出对更大但延迟的奖励的选择减少。安非他酮治疗阻断了尼古丁对雌性大鼠决策的影响，因为它们显示的结果接近基线水平。另一方面，安非他酮对尼古丁诱导的雄性大鼠延迟折扣没有影响。这些发现证明了尼古丁对认知冲动的两性二态效应，这可能有助于揭示在女性中观察到的尼古丁使用脆弱性。
Enhancement in cognitive impulsivity and the resulting alterations in decision making serve as a contributing factor for the development and maintenance of substance use disorders. Nicotine-induced increases in impulsivity has been previously reported in male humans and rodents. Although the potential for sex differences in nicotine-induced impulsivity has not been examined. In the present study, male and female Sprague Dawley rats were submitted to a delay discounting task, in which several consecutive measures of self-control were taken. Firstly, rats were tested with vehicle, and next with nicotine doses of 0.4 and 0.8 mg/kg. Thereafter, chronic treatment with bupropion started, and the animals were tested again. Half the animals continued to receive 0.8 mg/kg of nicotine, while the rest received nicotine and also a daily dose of 30 mg/kg of bupropion. When the animals were first tested with nicotine, female rats showed a significant nicotine dose dependent increase of impulsive behavior, whereas male rats only showed a decrease on their elections of the larger but delayed reward under the highest dose of 0.8 mg/kg of nicotine. Treatment with bupropion blocked the effect of nicotine on decision making in female rats, as they showed results close to their baseline levels. On the other hand, bupropion did not affect the nicotine-induced delay discounting in male rats. These findings demonstrate sexually dimorphic effects of nicotine on cognitive impulsivity which may help to shed light nicotine use vulnerabilities observed in women.
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中断多巴胺对未来奖励编码的可取消成本和利益编码。
影响因子：
25
作者：
Gan JO;Walton ME;Phillips PE
通讯作者：
Phillips PE
影响因子：
1.6
作者：
Anderson KG;Diller JW
通讯作者：
Diller JW
影响因子：
1.6
作者：
Dallery, J;Locey, ML
通讯作者：
Locey, ML
影响因子：
2.3
作者：
Bruijnzeel, AW;Markou, A
通讯作者：
Markou, A
DOI：
10.1111/j.1749-6632.1997.tb52356.x
发表时间：
1997-01-01
期刊：
NEUROBIOLOGY OF SUICIDE
影响因子：
--
作者：
Brunner, D;Hen, R
通讯作者：
Hen, R