Is the new variant RHDV replacing genogroup 1 in Portuguese wild rabbit populations?
Is the new variant RHDV replacing genogroup 1 in Portuguese wild rabbit populations?
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DOI：
10.3390/v7010027
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发表时间：
2014-12-30
期刊：
影响因子：
--
通讯作者：
Esteves PJ
中科院分区：
文献类型：
--
作者：
Lopes AM;Correia J;Abrantes J;Melo P;Ramada M;Magalhães MJ;Alves PC;Esteves PJ
兔出血性疾病病毒（Lagovirus rabbit hemorrhagic disease virus， RHDV）是钩状病毒科的一员，通过引起兔出血性疾病（RHD）严重影响欧洲兔（Oryctolagus cuniculus）种群。RHDV被细分为6个基因组，但最近出现了一种具有独特遗传和抗原谱的新的RHDV变体。我们对2013年和2014年在葡萄牙野外发现的死亡兔子进行了一项研究，以确定这种新变体与传统RHDV的流行程度。对57份肝脏样本进行RHDV检测，阳性样本进行基因分型。所有的RHDV感染病例都是由新变种引起的。在葡萄牙流行的唯一前基因群G1未被检测到。因此，我们得出结论，新的RHDV变体正在葡萄牙取代G1，可能是由于选择优势。这种突然而迅速的替代强调了继续监测野兔种群的必要性。
The Lagovirus rabbit hemorrhagic disease virus (RHDV), a member of the family Caliciviridae, severely affects European rabbit (Oryctolagus cuniculus) populations by causing rabbit hemorrhagic disease (RHD). RHDV is subdivided in six genogroups but, more recently, a new RHDV variant with a unique genetic and antigenic profile emerged. We performed a study in rabbits found dead in the field during 2013 and 2014 in Portugal to determine the prevalence of this new variant versus the classical RHDV. Fifty-seven liver samples were screened for the presence of RHDV and positive samples were genotyped. All cases of RHDV infection were caused by the new variant. The only former genogroup circulating in Portugal, G1, was not detected. We hence conclude that the new RHDV variant is replacing G1 in Portugal, probably due to a selective advantage. This sudden and rapid replacement emphasizes the necessity of continued monitoring of wild rabbit populations.
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