Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
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DOI：
10.3390/nu9121280
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发表时间：
2017-11-24
期刊：
影响因子：
5.9
通讯作者：
Asemi Z
中科院分区：
文献类型：
--
作者：
Jamilian M;Foroozanfard F;Rahmani E;Talebi M;Bahmani F;Asemi Z
本研究旨在评估维生素D补充对胰岛素抵抗的多囊卵巢综合征（PCOS）患者代谢特征的影响。这项随机、双盲、安慰剂对照试验在90名胰岛素抵抗的PCOS妇女中进行。参与者被随机分为三组，每天摄入4000 IU维生素D或1000 IU维生素D或安慰剂（每组n = 30），持续12周。与维生素D（1000 IU）和安慰剂相比，维生素D补充剂（4000 IU）导致总睾酮显著降低（分别为−0.2 ± 0.2 vs −0.1 ± 0.6和+0.1 ± 0.2 ng/mL，p = 0.02），游离雄激素指数（FAI）（分别为−0.06 ± 0.12 vs. −0.02 ± 0.12和+0.004 ± 0.04，p = 0.04），多毛症（分别为−1.1 ± 1.1 vs. −0.8 ± 1.2和−0.1 ± 0.4，p = 0.001）和高敏C反应蛋白（hs-CRP）（分别为−0.7 ± 1.4 vs. −0.5 ± 0.9和+0.5 ± 2.4 mg/L，p = 0.01）。此外，我们发现性激素结合球蛋白（SHBG）的平均变化显著升高，（分别为+19.1 ± 23.0 vs. +4.5 ± 11.0和+0.7 ± 10.4 nmol/L，p < 0.001）和总抗氧化能力（TAC）高剂量维生素D组与低剂量维生素D组和安慰剂组相比（分别为+130 ± 144 vs. +33 ± 126和−36 ± 104 mmol/L，p < 0.001）。总的来说，与低剂量维生素D和安慰剂组相比，胰岛素抵抗的PCOS妇女给予高剂量维生素D 12周对总睾酮、SHBG、FAI、血清hs-CRP和血浆TAC水平有有益的影响。
This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants were randomly assigned to three groups to intake either 4000 IU of vitamin D or 1000 IU of vitamin D or placebo (n = 30 each group) daily for 12 weeks. Vitamin D supplementation (4000 IU), compared with vitamin D (1000 IU) and placebo, led to significant reductions in total testosterone (−0.2 ± 0.2 vs. −0.1 ± 0.6 and +0.1 ± 0.2 ng/mL, respectively, p = 0.02), free androgen index (FAI) (−0.06 ± 0.12 vs. −0.02 ± 0.12 and +0.004 ± 0.04, respectively, p = 0.04), hirsutism (−1.1 ± 1.1 vs. −0.8 ± 1.2 and −0.1 ± 0.4, respectively, p = 0.001) and high-sensitivity C-reactive protein (hs-CRP) (−0.7 ± 1.4 vs. −0.5 ± 0.9 and +0.5 ± 2.4 mg/L, respectively, p = 0.01). In addition, we found significant elevations in mean change of sex hormone-binding globulin (SHBG) (+19.1 ± 23.0 vs. +4.5 ± 11.0 and +0.7 ± 10.4 nmol/L, respectively, p < 0.001) and total antioxidant capacity (TAC) (+130 ± 144 vs. +33 ± 126 and −36 ± 104 mmol/L, respectively, p < 0.001) in the high-dose vitamin D group compared with low-dose vitamin D and placebo groups. Overall, high-dose vitamin D administration for 12 weeks to insulin-resistant women with PCOS had beneficial effects on total testosterone, SHBG, FAI, serum hs-CRP and plasma TAC levels compared with low-dose vitamin D and placebo groups.
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影响因子：
7.1
作者：
Mitchell, Deborah M.;Leder, Benjamin Z.;Burnett-Bowie, Sherri-Ann M.
通讯作者：
Burnett-Bowie, Sherri-Ann M.
补充维生素 D 对循环高敏 C 反应蛋白水平的影响：随机对照试验的荟萃分析
影响因子：
5.9
作者：
Chen N;Wan Z;Han SF;Li BY;Zhang ZL;Qin LQ
通讯作者：
Qin LQ
影响因子：
5
作者：
Jamka, Malgorzata;Wozniewicz, Malgorzata;Stelmach-Mardas, Marta
通讯作者：
Stelmach-Mardas, Marta
DOI：
10.1016/j.ejogrb.2006.10.038
发表时间：
2007-08-01
影响因子：
2.6
作者：
de Paula Martins, Wellington;Santana, Laura F.;dos Reis, Rosana M.
通讯作者：
dos Reis, Rosana M.
影响因子：
81.5
作者：
Azziz, Ricardo;Carmina, Enrico;Yildiz, Bulent O.
通讯作者：
Yildiz, Bulent O.