Interactive effects of HIV/AIDS, body mass, and substance abuse on the frontal brain: a P300 study.
Interactive effects of HIV/AIDS, body mass, and substance abuse on the frontal brain: a P300 study.
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DOI：
10.1016/j.psychres.2009.08.020
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发表时间：
2011-01-30
影响因子：
11.3
通讯作者：
Bauer, Lance O.
中科院分区：
文献类型：
--
作者：
Bauer, Lance O.
鉴于艾滋病毒/艾滋病患者中体重超重的流行率不断上升，临床医生现在必须注意两者同时发生可能导致的不良后果。本研究旨在检验艾滋病毒/艾滋病和超重的附加和相互作用效应，以及药物滥用或依赖的额外贡献。因变量是通过测量P300脑电图电位来估计脑功能。在使用额叶（P300a）和额叶和非额叶（P300b）发生器诱发子成分的任务中，记录了P300电位。分析显示，102名HIV-1血清阳性受试者的额叶P300a潜伏期高于68名血清阴性受试者。此外，HIV-1血清状态与体重指数(BMI)≥25 kg/m2的协同相互作用进一步增加了额部P300a潜伏期。药物滥用/依赖史并没有改变这些变化。然而，它与艾滋病毒/艾滋病合并后产生的P300a振幅比没有任何疾病的参与者要小。研究结果表明，伴随BMI过高的白质变化可能会加剧那些患有艾滋病毒/艾滋病的人，从而减缓大脑额叶功能。药物滥用同样与艾滋病毒/艾滋病相互作用，但可能通过不同的机制损害大脑额叶功能。
In view of the rising prevalence of an overweight body mass among patients living with HIV/AIDS, clinicians must now be mindful of possible adverse outcomes resulting from the co-occurrence. The present study was designed to examine the additive and interactive effects of HIV/AIDS and an excess body mass, as well as the additional contributions of substance abuse or dependence. The dependent variable was brain function estimated by the measurement of P300 electroencephalographic potentials. P300 potentials were recorded during a task designed to elicit subcomponents with frontal (P300a) and both frontal and nonfrontal (P300b) generators. Analyses revealed greater frontal P300a latencies among the 102 HIV-1 seropositive versus the 68 seronegative participants. In addition, frontal P300a latency was further increased by a synergistic interaction of HIV-1 serostatus with a body mass index (BMI) ≥ 25 kg/m2. A history of substance abuse/dependence did not alter these changes. However, it did combine with HIV/AIDS to produce a smaller P300a amplitude than was seen in participants with neither disorder. The findings suggest that white matter changes accompanying an excess BMI may exacerbate those that attend HIV/AIDS and thereby slow frontal brain function. Substance abuse likewise interacts with HIV/AIDS but may impair frontal brain function via a different mechanism.
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期刊：
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