Left, but not right, rostrolateral prefrontal cortex meets a stringent test of the relational integration hypothesis.

Left, but not right, rostrolateral prefrontal cortex meets a stringent test of the relational integration hypothesis.
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DOI:
10.1016/j.neuroimage.2009.01.064
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发表时间:
2009-05-15
期刊:
影响因子:
5.7
通讯作者:
Wendelken C
Wendelken C
中科院分区:
医学1区
文献类型:
--
作者:
Bunge SA;Helskog EH;Wendelken C

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关于人类头外侧前额叶皮层(RLPFC;外侧布罗德曼区 10)功能的大部分了解都是通过过去十年的功能磁共振成像 (fMRI) 研究拼凑而成的。 Christoff 及其同事之前报道了一项涉及关系整合的 fMRI 定位器任务,该任务可靠地参与个体参与者的 RLPFC(Smith, R.、Keramatian, K. 和 Christoff, K. (2007)。在个体层面定位头外侧前额皮质。NeuroImage, 36(4), 1387–1396)。在这里,我们报告了该任务的修改版本,该版本可以更好地控制关系集成条件下的较低级别处理需求。在我们的实验和控制条件下使用相同的刺激阵列,我们发现右 RLPFC 对增加的关系处理需求很敏感,而无需在关系集成期间专门参与。相比之下,只有当参与者必须考虑两个个体关系之间的高阶关系时,左 RLPFC 才会参与。我们认为,左 RLPFC 整合不同的心理关系是支持人类高级认知的基本过程。
Much of what is known about the function of human rostrolateral prefrontal cortex (RLPFC; lateral Brodmann area 10) has been pieced together from functional magnetic resonance imaging (fMRI) studies over the past decade. Christoff and colleagues previously reported on an fMRI localizer task involving relational integration that reliably engages RLPFC in individual participants (Smith, R., Keramatian, K., and Christoff, K. (2007). Localizing the rostrolateral prefrontal cortex at the individual level. NeuroImage, 36(4), 1387–1396). Here, we report on a modified version of this task that better controls for lower-level processing demands in the relational integration condition. Using identical stimulus arrays for our experimental and control conditions, we find that right RLPFC is sensitive to increasing relational processing demands, without being engaged specifically during relational integration. By contrast, left RLPFC is engaged only when participants must consider the higher-order relationship between two individual relations. We argue that the integration of disparate mental relations by left RLPFC is a fundamental process that supports higher-level cognition in humans.
DOI: 10.1093/cercor/bhj113
发表时间: 2006-12-01
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影响因子: 3.7
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