Advanced hydrogels for the repair of cartilage defects and regeneration.
Advanced hydrogels for the repair of cartilage defects and regeneration.
复制标题
用于修复软骨缺损和再生的先进水凝胶
DOI：
10.1016/j.bioactmat.2020.09.030
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发表时间：
2021-04
影响因子：
18.9
通讯作者：
Ouyang H
中科院分区：
文献类型：
--
作者：
Wei W;Ma Y;Yao X;Zhou W;Wang X;Li C;Lin J;He Q;Leptihn S;Ouyang H
骨关节炎（OA）是一种退行性疾病，影响全球数百万人，并给社会带来重大的社会经济负担。水凝胶是一类具有弹性的生物材料，在显示出高含水量的同时显示出光滑的表面，是软骨再生的有希望的候选物。近年来，各种水凝胶被开发并应用于体外或体内软骨缺损的修复，其中一些有望进入临床试验。本文综述了近年来水凝胶修复软骨缺损的研究进展。我们讨论了软骨再生的原理，并概述了部署水凝胶用于医疗应用必须满足的要求。我们还强调开发具有针对不同类型软骨缺损的定制特性的先进水凝胶，以满足软骨组织工程和精准医学的要求。水凝胶应用于关节软骨缺损修复和软骨再生。水凝胶是三维亲水性聚合物网络，其可以由合成聚合物、多糖、蛋白质和肽制造，并且可以设计为可注射或原位形成以用于实际临床应用。开发水凝胶修复软骨缺损的生物技术是有前途的。综述了水凝胶用于软骨再生的原理和临床转化的要求。先进的水凝胶与定制性能的不同类型的软骨缺损进行了讨论。
Cartilage defects are one of the most common symptoms of osteoarthritis (OA), a degenerative disease that affects millions of people world-wide and places a significant socio-economic burden on society. Hydrogels, which are a class of biomaterials that are elastic, and display smooth surfaces while exhibiting high water content, are promising candidates for cartilage regeneration. In recent years, various kinds of hydrogels have been developed and applied for the repair of cartilage defects in vitro or in vivo, some of which are hopeful to enter clinical trials. In this review, recent research findings and developments of hydrogels for cartilage defects repair are summarized. We discuss the principle of cartilage regeneration, and outline the requirements that have to be fulfilled for the deployment of hydrogels for medical applications. We also highlight the development of advanced hydrogels with tailored properties for different kinds of cartilage defects to meet the requirements of cartilage tissue engineering and precision medicine. Hydrogels applied in joints for the repair of cartilage defects and cartilage regeneration. Hydrogels are three-dimensional hydrophilic polymer networks that can be fabricated from synthetic polymers, polysaccharides, protein, and peptides, and can be designed as injectable or in situ forming for practical clinical application. The biotechnology of developing hydrogels for cartilage defects repair is promising. The principle for cartilage regeneration using hydrogels and requirements for clinical transformation are summarized. Advanced hydrogels with tailored properties for different kinds of cartilage defects are discussed.
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影响因子：
4.6
作者：
Alakpa EV;Jayawarna V;Burgess KEV;West CC;Péault B;Ulijn RV;Dalby MJ
通讯作者：
Dalby MJ
影响因子：
4.6
作者：
Aisenbrey EA;Tomaschke A;Kleinjan E;Muralidharan A;Pascual-Garrido C;McLeod RR;Ferguson VL;Bryant SJ
通讯作者：
Bryant SJ
影响因子：
9.7
作者：
Boyer, Cecile;Figueiredo, Lara;Rethore, Gildas
通讯作者：
Rethore, Gildas
影响因子：
9.7
作者：
Balakrishnan, Biji;Joshi, Nitin;Banerjee, Rinti
通讯作者：
Banerjee, Rinti
DOI：
10.1055/s-2006-933445
发表时间：
2006-05-01
期刊：
ZEITSCHRIFT FUR ORTHOPADIE UND IHRE GRENZGEBIETE
影响因子：
--
作者：
Andereya, S.;Maus, U.;Schneider, U.
通讯作者：
Schneider, U.